转录因子Sp3表达与胰腺癌临床病理特征及预后的关系

Correlation of transcription factor Sp3 expression with clinical and pathological characteristics and prognosis of pancreatic cancer

目的通过研究胰腺癌组织内转录因子Sp3的表达及其与胰腺癌患者临床病理特征及预后的关系,探讨转录因子Sp3作为胰腺癌预后预测指标的可行性。方法对93例根治性切除术的胰腺癌肿瘤组织芯片进行免疫组化检测Sp3的表达情况,分析其与胰腺癌患者临床病理特征及预后之间的关系。结果免疫组化结果显示Sp3在胰腺癌组织中表达明显高于正常胰腺组织。进一步分析显示Sp3表达与胰腺癌患者术后总体生存率呈负相关,而与胰腺癌患者术后复发率呈正相关。结论转录因子Sp3在胰腺癌中明显高表达,可作为胰腺癌患者预后的独立预测指标。

【Objective】To explore the clinical significance of transcription factor Sp3 expression in pancreatic cancer and the correlation between Sp3 expression and survival of pancreatic cancer patients.【Methods】With the use of immunoreactivity, Sp3 expression and its correlation with other clinicopathological characteristics were examined in a tissue microarray that contained samples from 93 pancreatic cancer patients.【Results】Pancreatic cancer tissues expressed markedly higher levels of Sp3 than the normal pancreatic tissues did. The expression of Sp3 was negatively correlated with the overall survival and positively correlated with recurrence rate in pancreatic cancer patients after curative resection. 【Conclusion】Transcription factor Sp3 may be an independent prognostic factor for both overall survival and cumulative recurrence rate.