摘要
目的研究分析Galectin-3、HBME-1和VEGF在甲状腺乳头状癌中的表达状态及在临床病理诊断中的应用价值。方法采用免疫组化法分别检测32例甲状腺乳头状癌和30例结节性甲状腺肿中Galectin-3、HBME-1和VEGF的表达。结果 Galectin-3、HBME-1和VEGF在甲状腺乳头状癌中的阳性表达率分别为93.75%、90.60%和86.70%,三种抗体在甲状腺乳头状癌和良性病变中的阳性表达差异均有统计学意义。应用三种抗体行联合检测后,其敏感性为75.0%,特异性达100.0%,诊断正确率为87.5%,阳性预测值为100.0%,阴性预测值达82.2%。三种抗体在乳头状癌淋巴结转移组中的表达均高于淋巴结无转移组,但统计学分析证实无明显相关性。结论 Galectin-3、HBME-1和VEGF在甲状腺乳头状癌中的表达均有增强,三种抗体联合应用的特异性比两种联用或单个抗体应用更高,对诊断甲状腺乳头状癌更具有价值,Galectin-3、HBME-1和VEGF对于预测甲状腺乳头状癌淋巴结转移的意义不大。
【Objective】To investigate the expressions of galectin-3, HBME-1 and VEGF in papillary thyroid carcinoma（PTC） and their diagnostic values. 【Methods】Imunohistochemical technique was applied to detect the expressions of galectin-3, HBME-1 and VEGF in 32 cases with papillary thyroid carcinoma and 30 cases with multinodular goiters.【Results】The positive expression rates of galectin-3, HBME-1 and VEGF in papillary thyroid carcinoma were 93.75%, 90.60% and 86.70%, which were significantly different from those in multinodular goiters.The sensibility, specificity, accuracy rate, positive predictive value and negative predictive value of using a combination of galectin-3, HBME-1 and VEGF in differentiation of benign lesions from papillary thyroid carcinoma were75.0%, 100.0%, 87.5%, 100.0%, 82.2%, respectively. No significant relationship was found, although the expressions of galectin-3, HBME-1 and VEGF in thyroid papillary carcinoma with lymph node metastasis were higher than those in thyroid papillary carcinoma without lymph node metastasis. 【Conclusions】 The expression levels of galectin-3, HBME-1 and VEGF in papillary thyroid carcinoma are significantly higher than those in benign thyroid papillary hyperplasia. A combination of the three kinds of antibodies can make a correct differential diagnosis between papillary thyroid carcinoma and its benign mimics. Galectin-3, HBME-1 and VEGF may be of little significance for predicting lymph node metastasis in papillary thyroid carcinoma.
出处
《中国现代医学杂志》
CAS
北大核心
2015年第18期26-30,共5页
China Journal of Modern Medicine
