非对称性二甲基精氨酸检测在妊娠期高血压疾病中的临床意义

Clinical significance of asymmetric dimethylarginine detection for gestational hypertension diseases

目的探讨检测血清非对称性二甲基精氨酸(ADMA)在妊娠期高血压疾病中的临床意义。方法选择伴或不伴妊娠期高血压疾病的孕产妇各50例分别作为观察组和对照组,比较两组血清ADMA及一氧化氮(NO)水平,并分析不同妊娠高血压疾病患者中ADMA及NO的水平。结果观察组ADMA水平(3.8±0.8)μmol/L较对照组的(2.4±0.6)μmol/L显著升高(P<0.01);NO水平(36.2±10.6)μmol/L较对照组的(56.8±16.2)μmol/L显著降低(P<0.01)。与妊娠期高血压、妊娠合并慢性高血压相比,子痫前期、子痫及慢性高血压并发子痫前期患者血清ADMA水平显著增高(P<0.05),而NO水平显著降低(P<0.05)。结论血清ADMA的检测有助于妊娠期高血压疾病的早期诊断,并且有助于判断子痫前期及子痫。

Objective To explore the clinical significance of asymmetric dimethylarginine detection for gestational hypertension diseases. Methods Fifty women with gestational hypertension diseases were selected as observation group, and another 50 pregnant women without hypertension diseases were enrolled as control group. Comparison was made in the levels of serum ADMA and nitrogen between the two groups. And analysis was made in the levels of ADMA and nitrogen among patients with different gestational hypertension diseases, Results The levels of ADMA in the observation group （3.8：t：0.8）μmol/L obviously increased compared with that of the control group （2.4±0.6）μmol/L （P 〈 0.01）, while the level of nitrogen in the former group （36.2±10.6）μmol/L decreased significantly compared with that of the latter group （56.8±16.2）μmol/L （P 〈 0.01）. The levels of ADMA in patients with pre-eclampsia, eclampsia, and chronic hypertension complicated with eclampsia significantly increased, while the levels of nitrogen decreased significantly compared with those in patients with gestational period hypertension and pregnancy combined with hypertension （P 〈 0.05）. Conclusion The detection of serum ADMA is helpful to the early diagnosis of gestational hypertension diseases and also the judgment of pre-eclampsia and eclampsia.