纤维蛋白原对急性冠状动脉综合征患者介入治疗后远期心血管事件的预测价值被引量：3

Value of fibrinogen in predicting long-term cardiovascular events in patients with acute coronary syndrome after intervention treatment

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摘要目的探讨纤维蛋白原对首次诊断为急性冠状动脉综合征（ACS）且接受早期介入治疗患者远期预后的预测价值.方法采用回顾性病例对照研究,对首次诊断为ACS且接受早期介入治疗患者进行随访,随访中位时间为1 037 d,将出现主要心血管不良事件（MACE）（包括非计划性再次血运重建、非致死性心肌梗死和心源性死亡）的39例患者作为MACE组,年龄、性别及发病时间相互匹配但未出现MACE的39例患者作为非MACE组,比较2组患者血清N末端前脑钠肽、肌钙蛋白T、肌酸激酶同工酶、肌酐、高敏C反应蛋白、纤维蛋白原等相关指标的差异.结果 MACE组患者纤维蛋白原水平明显高于非MACE组患者[（3.3±0.8）g/L比（3.0 ±0.5）g/L] （P ＜0.05）,且经过校正多个临床特征后,纤维蛋白原仍与ACS患者的预后独立相关（危险比=1.602,95％置信区间：1.011 ～2.539,P＜0.05）.结论对于首次诊断ACS且接受早期介入干预治疗的患者,纤维蛋白原可能是其预后的独立预测因子. Objective To investigate the value of fibrinogen in predicting long-term cardiovascular events in patients with acute coronary syndrome （ACS） after intervention treatment.Methods A retrospective analysis was performed among patients of incipient ACS who received an early intervention treatment （median follow-up period of 1 037 days）.Major adverse cardiovascular events （MACE）,including unplanned revascularization,nonfatal myocardial infarction and sudden cardiac death,occurred in 39 patients who were set as MACE group;other 39 patients without MACE matching with MACE group on age and gender were set as non-MACE group.The baseline clinical characters,including N terminal pro brain natriuretic peptide,cardiac troponin T,creatine kinase isoenzyme,creatine,high sensitivity C reactive protein and fibrinogen,were compared between the two groups.Results The level of fibrinogen in MACE group were significantly higher than that in non-MACE group [（3.3 ± 0.8） g/L vs （3.0 ±0.5） g/L] （P 〈0.05）.After multivariable adjustment of clinical characteristics,fibrinogen was independently correlated with the prognosis of ACS （hazard ratio =1.602,95% confidence interval：1.011-2.539,P 〈 0.05）.Conclusion Fibrinogen may be an independent predictor of prognosis in patients with incipient ACS after early intervention treatment.

作者徐昕晔郭歌祖凌云高炜

机构地区北京大学第三医院心内科卫生部心血管分子生物学与调节肽重点实验室分子心血管教育部重点实验室

出处《中国医药》 2015年第8期1092-1095,共4页 China Medicine

基金国家自然科学基金（81300076）

关键词急性冠状动脉综合征纤维蛋白原预后主要心血管不良事件 Acute coronary syndrome Fibrinogen Prognosis Major adverse cardiovascular events

分类号 R541.1 [医药卫生—心血管疾病]

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