白细胞介素-38的研究进展

Advances in the study of interleukin-38

白细胞介素-1F10(IL-1F10)是IL-1家族中的第10个成员,现称为白细胞介素-38(IL-38)。有研究表明白细胞介素-36受体(IL-36R)是IL-38的特异性受体。IL-38基因序列与IL-1受体拮抗剂(IL-1Ra)、IL-36受体拮抗剂(IL-36Ra)基因序列高度同源。IL-38与IL-36Ra、IL-1Ra三者具有相似的生物学功能。本文主要对IL-38的分子结构,生物学特性、功能及其相关炎症性疾病作一综述。

Interleukin-1F10（IL-1F10）,now known as IL-38,is the 10 th member of the cytokine IL-1family.Studies have indicated that the interleukin-36receptor（IL-36R）is an IL-38-specific receptor and a partial IL-36 receptor antagonist（IL-36Ra）.The gene sequence of IL-38 is highly similar to that of IL-36 Ra and IL-1Ra.The forms of interleukin have similar biological functions.This paper summarizes advances in the study of the molecular structure,biological characteristics,and functions of IL-38,and this paper also summarizes the role of cytokines that are related to IL-38 in inflammatory diseases.