喉癌前病变中医证候特点的调查研究及聚类分析

Investigation and cluster analysis on the syndrome characteristics of precancerous laryngeal lesions

目的:通过流行病学调查了解喉癌前病变患者的证候分布规律。方法:对2008-2013年在广东省中医院住院及门诊就诊的214例确诊为喉癌前病变患者进行病例调查,采用指标聚类分析探讨证候分布规律。结果:结合专家意见,聚4类结果较为准确综合地反映证候的临床信息特征。具体包括湿热互结型、气虚痰瘀型、痰浊困结型和阴虚火旺型。其中气虚痰瘀型占比率最大(40.7%),阴虚火旺型、湿热互结型仅次之(分别为25.7%、22.9%),痰浊困结型比例较小(10.7%)。结论:喉癌前病变岭南地区患者的中医征候特点以气虚痰瘀证较多,气虚痰瘀是喉癌前病变的最主要病机所在。

Objective： To investigate the syndrome distribution law of the patients with precancerous laryngeal lesions by epidemiological survey. Methods： The 214 patients with laryngeal precancerosis from inpatient or outpatient of Guangdong TCM Hospital from 2008 to 2013 were surveyed, indicator cluster analysis was adopted to discuss the syndrone distribution law. Results： Combined with expert advice, poly-4 class results more accurately reflected the comprehensive features of the syndrome of clinical information, including damp-heat stagnation syndrome, qi deficiency and phlegm stasis syndrome, turbid phlegm accumulation syndrome, hyperactivity of fire due to yin deficiency syndrome. Among them, qi deficiency and phlegm stasis syndrome accounted for ratio of the maximum（40.7%）, hyperactivity of fire due to yin deficiency syndrome and damp-heat stagnation syndrome were the next（25.7%, 22.9%）, and turbid phlegm accumulation syndrome was the smaller proportion（10.7%）. Conclusion： Qi deficiency and phlegm stasis syndrome is more seen and comes to be the main TCM pathogenesis of laryngeal precancerous lesion in south region areas.