胰高血糖素样肽-1受体激活在脑缺血中的神经保护作用被引量：2

Neuroprotective effect of glucagon-like peptide-1 receptor activation in cerebral ischemia

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摘要胰高血糖素样肽-1（glucagon-like peptide 1,GLP-1）是肠促胰岛素的重要成员。经口进食可刺激末端回肠和结肠L 细胞分泌GLP-1。 GLP-1与特异性受体GLP-1受体（GLP-1 receptor, GLP-1R）结合后发挥促进葡萄糖依赖的胰岛素分泌、抑制胰高血糖素分泌和降低血浆胰高血糖素水平等作用。 GLP-1具有分子质量相对较小，可直接透过血脑屏障，且中枢和外周神经系统均有GLP-1R表达。 GLP-1可显著改善神经功能缺损和缩小梗死体积，其可能通过抑制炎症反应、氧化应激和细胞凋亡等机制发挥神经保护作用。文章就GLP-1的发现、生物学特性和在脑缺血中的神经保护作用进行了综述。 Glucagon-like peptide 1（GLP-1） is an important member of incretin.Takingitoralymay stimulate the terminal ileum and colon L cells to secrete GLP-1. After GLP-1 biding specific receptor GLP-1 receptor （ GLP-1R）, it exerts the roles of promoting glucose-dependent insulin secretion, inhibiting glucagon secretion, and decreasing plasma glucagon level. The molecular mass of GLP-1 is relatively smaller and can directly cross the blood-brain barrier, and both central and peripheral nervous systems have the GLP-1R expression. GLP-1 significantly improves neurological deficits and reduces infarct volume. It may exert neuroprotective effect through the mechanisms of inhibiting the inflammatory response, oxidative stress, and cell apoptosis. This article reviews the discovery of GLP-1, its biological characteristics and neuroprotective effect in cerebral ischemia.

作者韩玲薛国芳李东芳

机构地区山西医科大学第二医院神经内科

出处《国际脑血管病杂志》 2015年第5期378-382,共5页 International Journal of Cerebrovascular Diseases

基金山西省卫生厅科研课题（201201076）山西医科大学第二医院博士启动基金（20120406）

关键词脑缺血胰高血糖素样肽1 神经保护药 Brain Ischemia Glucagon-Like Peptide 1 Neuroprotective Agents

分类号 R743.31 [医药卫生—神经病学与精神病学]

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