子宫螺旋动脉血流参数联合血清孕酮、β-HCG检测在先兆流产预测中的价值

Value of Blood Flow Parameters of Uterine Spiral Artery Combined with Serum Progesterone and β-HCG Detection in Prediction of Threatened Abortion

目的研究子宫螺旋动脉血流参数联合血清孕酮、β-HCG检测在先兆流产预测中的价值。方法选择2013年4月至2014年6月我院收治的180例早孕妇女,分为正常妊娠组(92例)、先兆流产组(56例)以及流产组(32例)。三组均进行血清孕酮、β-HCG水平的测定,以及子宫螺旋动脉血流频谱的检测。结果流产组在第5周、第6周、第7周的血清孕酮水平明显低于先兆流产组和正常妊娠组,差异具有统计学意义(P<0.05)。在妊娠第5周时,三组孕妇的血清β-HCG水平差异无统计学意义(P>0.05),但在妊娠的第6、7周时,正常妊娠组孕妇的血清β-HCG水平明显高于先兆流产组和流产组,差异具有统计学意义(P<0.05)。流产组在第5周、第6周、第7周的RI明显高于先兆流产组和正常妊娠组,差异具有统计学意义(P<0.05)。结论子宫螺旋动脉血流参数联合血清孕酮、β-HCG检测在先兆流产中具有较高的预测价值,值得广泛推广使用。

Objective To explore the clinical value of blood flow parameters of uterine spiral artery combined with serum progesterone and β-HCG detection in prediction of threatened abortion. Methods 180 cases of early pregnant women were selected and divided into the normal pregnant group（n = 92）, threatened abortion group（n = 56） and abortion group（n = 32）. All cases received detections of serum progesterone and β-HCG, and uterine spiral artery blood flow spectrum detection, and the indicators were observed and compared among three groups. Results The level of serum progesterone at 5th, 6thand 7thweek of abortion group was significantly lower than that of normal pregnant group and threatened abortion group respectively（P 0.05）. No statistical difference was found among 3 groups in the serum β-HCG level at 5thweek, but at 6thand 7thweek, the serum β-HCG level of normal pregnant group was significantly higher than that of threatened abortion group and abortion group（P 0.05）. The RI of abortion group at 5th, 6thand 7thweek was significantly higher than that of normal pregnant group and threatened abortion group respectively（P 0.05）. Conclusions Blood flow parameters of uterine spiral artery combined with serum progesterone and β-HCG detection have high predictive value in threatened abortion.