吡啶类化合物氧化制备吡啶N-氧化物研究进展

Research Advances in the Oxidations of Pyridines Compounds to Pyridine N-oxides

介绍了吡啶N-氧化物类化合物作为反应产物和中间体等的应用,综述了吡啶类化合物经氧化反应制备吡啶N-氧化物的研究进展,总结了反应所用的氧化剂、催化剂等反应条件。认为目前最常用的过氧化氢在醋酸中的氧化法应解决产物分离和醋酸的高效回收利用问题;以水为溶剂的催化过氧化氢氧化最有发展前景,但需要解决原料的溶解性、产物的分离等问题。应加强对吡啶类化合物氧化制备吡啶N-氧化物的系统研究,及吡啶N-氧化物在有机合成中的应用研究。

This review briefly introduced the applications of pyridine N-oxides as reaction products and as synthetic intermediates,then summarized the advances in the oxidations of pyridine compounds to pyridine N-oxides in details, with particular emphasis on key reaction conditions such as oxidants and catalysts. The most commonly oxidation method of hydrogen peroxide in acetic acid should solve the problems such as separation of the product and high efficient recycling of acetic acid; catalytic hydrogen peroxide oxidation using water as solvent was the most promising method, but need to solve the problems such as solubility of raw materials,the separation of product and so on. Systematic studies on oxidations of pyridine compounds to pyridine N-oxides and the use of these pyridine N-oxides in organic synthesis should be strengthened.