期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PINK1与糖代谢相关的研究进展

The study progress on the correlation between PINKI and glucose metabolism
下载PDF
导出
摘要 同源性磷酸酶张力蛋白诱导的激酶1[phosphatase and tensin homologue(PTEN)-induced putative kinase 1,PINK1]是与帕金森相关的一种蛋白激酶,同线粒体功能密切相关。有研究表明,PINK1可能与肥胖、2型糖尿病(type 2 diabetes mellitus,T2DM)有关,在调节胰岛β细胞功能中有一定作用,某些治疗T2DM药物也参与PINK1途径调节。本文就近年关于PINK1与糖代谢相关研究进行综述。 PINK1 [phosphatase and tensin homologue （PTEN）-induced putative kinase 1 ] is a protein kinase associated with Parkinson＇s and closely related with mitochondrial function. Studies have shown that PINK1 may be involved in obesitr, type 2 diabetes. Recent studies demonstrate that PINK1 is necessary to maintain function of pancreatic beta cells. Some diabetic drugs are also involved in the regulation of PINK1. This article reviewed the study on the correlation between PINK1 and glucose metabolism in recent years.
作者 张娟 莫朝晖
机构地区 中南大学湘雅附三医院内分泌科
出处 《临床与病理杂志》 CAS 2015年第6期1175-1179,共5页 Journal of Clinical and Pathological Research
关键词 糖代谢 胰岛素抵抗 胰岛Β细胞 线粒体 PINK1 glucose metabolism insulin resistance pancreatic beta cell mitochondria
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献31

  • 1Valente EM, Bentivoglio AR, Dixon PH, et al. Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36[J]. AmJ Hum Genet, 2001, 68(4): 895-900.
  • 2Trempe JF, Fon EA. Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection[J]. Front Neurolj 2013, 4: 38.
  • 3Eiyama A, Okamoto K. PINK1/Parkin-mediated mitophagy in mammalian cells[J]. Curr Opin Cell Biol, 2015, 33: 95-101.
  • 4Murata H, Sakaguchi M, Kataoka K, et al. Multiple functions of PINK1 at different intracellular locations: beyond neurodegenerative diseases[J]. Cell Cyde, 2011, 10(10): 1518-1519.
  • 5Choi I, Kim J, Jeong HK, et al. PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR[J].Glia, 2013, 61(5): 800-812.
  • 6Chien WL, Lee TR, Hung SY, et al. Increase of oxidative stress by a novel PINK1 mutation, P209A[J]. Free Radic Biol Med, 2013, 58: 160-169.
  • 7Vincow ES, Merrihew G, Thomas RE, et al. qe PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo[J]. Proc Natl Acad Sci U S A, 2013, 110( 16): 6400-6405.
  • 8Akundi RS, Zhi L, Biieler H. PINK1 enhances insulin-like growth factor-l-dependent Akt signaling and protection against apoptosis[J]. Neurobiol Dis, 2012, 45 (1): 469-478.
  • 9Murata H, Sakaguchi M, Jin Y, et al. A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINKI: activation of AKT via mTORC2[J]. J Biol Chem, 2011,286(9): 7182-7189.
  • 10Dagda RK, Pien I, Wang R, et al. Beyond the mitochondrion: cytosolic PINKI remodels dendrites through protein kinase A[J].J Neurochem, 2014 128(6): 864-877.
临床与病理杂志
2015年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部