肺良性转移性子宫平滑肌瘤临床病理分析并文献复习

Clinicopathologic analyses of pulmonary benign metastasizing leiomyoma and review of the literature

目的:探讨肺良性转移性子宫平滑肌瘤(benign metastasizing leiomyoma,BML)的临床病理学特点及临床治疗。方法:对1例肺良性转移性子宫平滑肌瘤进行临床资料、病理形态学形态及免疫组织化学观察,并结合文献对其诊断及鉴别诊断、临床治疗、预后进行探讨。结果:肿瘤形态类似子宫平滑肌瘤,瘤细胞呈梭形,无细胞的非典型性,未见坏死,核分裂像罕见。免疫组织化学染色示肿瘤细胞:ER、PR、SMA、Calponin强阳性。结论:BML非常罕见,肺是常见转移部位,因缺乏对其认识,易与其他肿瘤混淆导致误诊。提高对BML的认识对避免误诊非常重要。

Objective： To explore the characteristics of clinicopathology, diagnostic criteria and differential diagnosis of benign metastasizing leiomyoma （BML）. Methods： The clinical data, histopathologic observation and immunohistochemical staining were studied in one case of BML, the related literatures were reviewed. Results： Microscopic examination of this case showed that the morphology was similar to the uterine leiomyoma, and the tumor was composed of spindle cell without marked nuclear atypia and mitosis. Immunohistochemicall）5 ER, PR, SMA, and calponin were strong positive. Conclusion： BML is very rare tumor, and the lung is the major site of metastasis. It is easily confused with other tumor leading to misdiagnosis. It is essential to avoid misdiagnosis with raising awareness.