仿骨β相磷酸三钙多孔生物陶瓷制备及降解

Preparation and degradation of porous β-tricalcium phosphate bioceramic for bone imitaion

以硝酸钙和2-膦酸丁烷-1,2,4-三羧酸(PBTC)为原料通过化学合成前驱体,然后脱水缩合再高温烧结的方法制备β相磷酸三钙(β-TCP)粉体,以该粉体为基体、硬脂酸为致孔剂、PVA为粘结剂,通过模压成型的方法制取胚体烧结制备β-TCP多孔生物陶瓷。通过X射线衍射分析、扫描电镜观察、EDX能谱成分分析对制备的β-TCP多孔陶瓷进行研究。对添加致孔剂质量分数分别为15%、20%、25%、30%的4组陶瓷试样进行降解试验,发现质量分数为30%的试样降解效果最好,通过扫描电镜观察和EDX分析确认表面有类羟基磷灰石物质产生。

In this study, porous β-tricalcium Phosphate （β-TCP） bioceramic is prepared by the following steps. First, calcium nitrate and 2-phosphonic acid-1, 2,4-tricarboxylic acid （PBTC） are used as raw materials to synthesize the precursor; second, β-TCP power was prepared by dehydration concentration and high temperature sintering; third, β-TCP power is taken as the matrix, stearic acid as porogen and PVA as binder to prepare the moudles by press molding; finally, β-TCP bioceramic is prepared by sintering of the moudles. The compositions of the β-TCP bioceramic are analyzed using X-ray diffraction analysis, scanning electron microscopy and EDX spectroscopy. Degradation experiments are carried out using the specimens with four levels of porogen, 15%, 20%, 25% and 30% respectively. Results show that the specimen with 30% of porogen has the best degradation performance. EDX analysis and scanning electron microscopy observation confirm the generation of hydroxyapatite materials on the surface of the β-TCP bioceramic.