冠心病经皮PCI治疗患者糖化血清清蛋白水平与冠状动脉病变的相关性研究

Research on the relevance between glycated serum albumin and severity of coronary artery disease of patients with percutaneous coronary intervention

目的探讨经皮冠状动脉介入治疗（PCI）的冠心病患者的糖化血清清蛋白（GA）水平与冠状动脉病变的关系。方法选取2012年3月至2014年3月在我院心内科拟诊断为冠心病并行冠状动脉造影检查的患者200例,根据造影结果分为冠状动脉造影阴性组45例（对照组）,冠状动脉造影阳性且行PCI组155例（PCI组）。采用冠状动脉造影及Gensini积分法分析冠脉病变程度,并检测所有患者的GA水平。结果对照组和PCI组的GA水平分别为（14.17±3.16）%和（15.72±2.98）%,差异有统计学意义（P〈0.05）。根据Gensini积分进行分组,其中对照组、1~30分组、31~60分组、〉60分组的GA水平分别为（14.17±3.16）%、（14.31±3.21）%、（16.45±4.57）%、（16.63±3.85）%,差异有统计学意义（P〈0.05）。根据病变支数分组,与对照组比较,双支组及多支组GA水平均明显升高,差异有统计学意义（P〈0.05）。与单支组及双支组比较,多支组GA水平亦明显升高（P〈0.05）。不同GA水平组的病变支数分布及Gensini积分分布差异均有统计学意义（P〈0.05）。结论经PCI手术的冠心病患者GA水平较冠状动脉病变阴性患者显著升高,GA水平与冠状动脉病变的支数和严重程度密切相关。

Objective To explore the relationship between glycated albumin（GA） levels and severity of coronary artery in coronary heart disease patients with percutaneous coronary intervention（PCI）. Methods Two hundred patients with coronary heart disease who underwent coronary angiography examination from March 2012 to March 2014 in the Department of Cardiology in our hospital were selected. They were allocated to coronary angiography negative group（control group, 45 patients） and coronary angiography positive with PCI group（PCI group, 155 patients）. Coronary angiography and Gensini integral method were used to analyze the severity of coronary artery disease and all patients’ GA level were tested. Results GA levels of control group and PCI group were（14.17±3.16）% and（15.72±2.98）% respectively, and the difference was statistically significant（P〈0.05）. The group was divided into control group, 1~30 group, 31~60 group and 〉60 group according to the Gensini integral test with the GA levels of（14.17±3.16）%,（14.31±3.21）%,（16.45±4.57）%,（16.63±3.85）%, respectively, and the difference was statistically significant（P〈0.05）. According to the number of coronary artery lesions, GA levels of double vessels group and multi vessels group were significantly elevated compared to those of control group（P〈0.05）. GA levels of multi vessels group were also increased significantly compared with those of the single vessel group and double vessels group（P〈0.05）. The differences in the distribution of the number of coronary artery lesions and Gensini integral in different GA groups were statistically significant（P〈0.05）. Conclusion GA level of patients with PCI is significantly increased compared with that of patients with negative coronary artery lesion.GA level is significantly correlated with the number of coronary artery lesions and severity of coronary artery disease.