认知行为干预晚期肺癌化疗患者焦虑、抑郁模式分析

Analysis of cognitive behavior intervention on anxiety and depression during chemotherapy in patients with advanced lung cancer

目的探索认知行为干预(CBI)治疗模式对晚期肺癌化疗患者焦虑、抑郁的疗效。方法随机将100例晚期肺癌化疗患者(ⅢB期或Ⅳ期)均分为4组:第1组予CBI干预治疗晚期肺癌化疗患者及家属,第2组予CBI干预晚期肺癌化疗患者,第3组予CBI干预患者家属,第4组为无CBI干预组,干预时间持续4周,分别采用焦虑自评量表(SAS)、抑郁自评量表(SDS)进行CBI干预治疗前后SAS、SDS差值计算。结果 4组晚期肺癌化疗患者SAS差值、SDS差值比较,差异有统计学意义(P<0.05),其中第1组干预治疗模式SAS、SDS值显著下降。结论 CBI干预晚期肺癌化疗患者及家属治疗模式明显改善晚期肺癌化疗患者焦虑及抑郁状况。

Objective To investigate the efficacy of cognitive behavior intervention（CBI） on anxiety and depression in pa- tients with advanced lung cancer who received chemotherapy. Methods Patients with advanced lung cancer （n= 100） who agreed to participate in the study were equally randomized to the first arm, the second arm,the third arm and the last arm. Patients in the for- mer three groups received CBI on patients and their family members /patients / family members respectively for 4 weeks across chemotherapy,whereas the last group received chemotherapy only. The benefits of the CBI were evaluated using the zung self-rating anxiety scale （SAS） to assess anxiety,the zung self-rating depression scale （SDS） to measure depression before and after the CBI. Results Patients among the 4 groups showed significantly statistical difference about scores of SAS and SDS（P〈0.05）. The SAS and SDS value decreased significantly in the first group. Conclusion CBI is an effective approach that can improve patientsr mood with advanced lung cancer received chemotherapy obviously.