MACC1和c-Met蛋白在胃印戒细胞癌中的表达及意义

Expression of MACC1 and c-Met Proteins in Signet Ring Cell Carcinoma and Its Significance

[目的]探讨结肠癌转移相关基因1(metastasis-associated in colon cancer 1,MACC1)和肝细胞生长因子受体(hepatocyte growth factor receptor,c-Met)在胃印戒细胞癌(signet ring cell carcinoma,SRCC)组织中的表达及其与临床病理特征的相关性。[方法 ]应用免疫组化法检测80例SRCC组织及其对应癌旁组织和25例癌前病变组织中MACC1和c-Met蛋白的表达情况,统计学分析MACC1和c-Met表达水平与临床病理特征的关系。[结果]MACC1和c-Met在SRCC组织中的阳性率均明显高于癌旁组织和癌前病变组织(P<0.05)。MACC1和c-Met阳性率均与肿瘤浸润深度、TNM分期、淋巴结转移和腹膜转移相关(P<0.05),而与年龄、性别、肿物部位、大小、CEA和CA199无统计学意义相关(P>0.05)。SRCC组织中MACC1和c-Met的表达呈正相关(r=0.301,P=0.007)。[结论]MACC1和c-Met在SRCC的侵袭和转移过程中发挥重要作用,有望成为SRCC预后的标志及潜在治疗靶点。

[Purpose] To investigate the expression of metastasis-associated in colon cancer 1（MACC1）and hepatocyte growth factor receptor（c-Met） in signet ring cell carcinoma（SRCC） and its relationship with clinical features. [Methods] The expression of MACC1 and c-Met in 80 cases of SRCC,80 cases of paracancerous lesion and 25 cases of para-cancerous lesion was detected with immunohistochemistry. The correlation of the expression of MACC1 and c-Met in SRCC with clinicopathological parameters was analyzed. [Results] The positive expression rates of MACC1 and c-Met proteins in SRCC were significantly increased than those in precancerous lesion and para-cancerous（P〈0.05）. MACC1 and c-Met expression correlated to depth of tumor invasion,TNM stage,lymph node metastasis and peritoneal metastasis（P〈0.05）,but did not correlated to gender,age,tumor size,tumor location,CEA and CA199. In addition,MACC1 expression was positively correlated with c-Met（r=0.301,P=0.007）. [Conclusions] MACC1 and c-Met play an important role in the invasion and metastasis of SRCC. MACC1 and c-Met could consider as biomarkers and new targets for SRCC therapy.