脂微球化前列腺素E1在严重下肢缺血患者中的短期疗效

Short term effects of lipo-prostaglandin E1 in treating patients with critical limb ischemia

目的观察脂微球化前列腺素E1(PGE1)在严重下肢动脉缺血患者中的治疗效果。方法回顾性分析本院自2005年7月至2013年3月期间,82例下肢动脉硬化所致严重下肢缺血(CLI)并且无法行手术或者腔内血管重建的患者临床资料,以及治疗2周前后下肢静息痛疼痛分级情况、额外镇痛药物的应用和踝肱指数变化,从而评价脂微球化PGE1的短期疗效。结果 82例患者下肢静息痛改善的总有效率为75.6%,第2周患者平均额外镇痛药物的应用较第1周显著减少(P<0.05),治疗前后踝肱指数水平差异无统计学意义(P>0.05)。治疗前后无严重不良反应发生。结论脂微球化PGE1能在短期内显著改善CLI患者的静息痛症状,不良反应小,可作为此类患者药物治疗的首选。

[ABSTRACT] AIM To observe short term therapeutic effect of lipo-prostaglandin E1 （lipo PGE1） in treating pa- tients with critical limb ischemia（CLI）. METHODS From July 2005 to March 2013, 82 patients with CLI and revascu- larization intolerance were enrolled. Rest pain grading,extra administration of analgesic and ankle-brachial index （ABI） was evaluated after the treatment with lipo PGE1 for 2 weeks. RESULTS After 2 weeks treatment, the effective rate of rest pain relief were 85.0 % in patients with rest pain grade Ⅱ, and it was 66.7 % in patients with rest pain grade Ⅲ.The total effective rate of rest pain relief was 75.6 %. The average extra administration of analgesic duced in the second week, compared to the first week. There was no significant difference in changes was statistically re- of ABI level before and after treatment （ P 〉 0.05 ）. No severe adverse drug reactions of lipo PGE1 was observed. CONCLUSION Lipo PGEI is suitable for CLI patients with poor conditions and concomitant diseases who are not eligible for arterial revascular- ization. In a short treatment circle, lipo PGE1 is an appropriate treat strategy. It can be effectively and safely applicatied in CLI patients, especially to release the rest pain.