摘要
目的探讨CT引导下125I放射性粒子植入联合吉西他滨和替吉奥(GS)化疗方案治疗中晚期胰腺癌的疗效及安全性。方法将68例无手术指征的中晚期胰腺癌患者随机分为两组。A组38例接受125I粒子植入联合GS化疗方案,B组30例接受GS化疗方案。比较两组近期疗效、中位无进展生存时间(m PFS)、中位生存时间(m OS)和不良反应。结果 A组客观有效率、疾病控制率和临床受益率(ORR、DCR和CBR)分别为57.9%、73.7%、84.2%,B组分别为26.7%、46.7%、60.0%,两组比较差异均有统计学意义(P<0.05);A组m PFS、m OS分别为8.0、11.8个月,高于B组5.6、10.4个月,差异有统计学意义(P<0.05);消化道反应、血液毒性及肝毒性等不良反应,差异无统计学意义(P>0.05)。结论对于中晚期胰腺癌患者,CT引导下125I放射性粒子植入联合GS方案是一种安全、有效的治疗手段。
Objective To evaluate the efficacy and safety of CT-guided125 I radioactive seed implantation combined with gemcitabine and Gio（gemcitabine and S-1, GS scheme） chemotherapy in treating advanced pancreatic carcinoma. Methods Sixty-eight patients with inoperable advanced pancreatic carcinoma were randomly divided into two groups. Patients in group A（n=38） were treated with CT-guided125 I radioactive seed implantation combined with GS chemotherapy scheme, while patients in group B（n =30） received GS chemotherapy scheme only. The short-term effect, the median progression-free survival time, the median survival time and adverse reactions of the two groups were determined, and the results were compared between the two groups. Results The objective response rate（ORR）, disease control rate（DCR） and clinical benefit rate（CBR） of the group A were 57.9%, 73.7% and 84.2% respectively, while those of group B were26.7%, 46.7% and 60.0% respectively. The differences between the two groups were statistically significant（P〈0.05）. In group A the median progression-free survival time and the median survival time were 8.00 months and 11.84 months respectively, which were strikingly higher than those in group B（5.63 months and10.40 months respectively）, the differences between the two groups were statistically significantly（P〉0.05）.No significant differences in gastrointestinal reactions, blood toxicity, liver toxicity and other adverse reactions existed between the two groups（P〈0.05）. Conclusion For advanced pancreatic carcinoma, CT-guided125 I radioactive seed implantation combined with GS program is a safe and effective treatment.
出处
《介入放射学杂志》
CSCD
北大核心
2015年第6期494-497,共4页
Journal of Interventional Radiology
基金
昌乐县科技发展计划项目(乐科字第201424号)
