癫癎猝死机制进展

Recent Advances in Mechanisms of Sudden Unexpected Death in Epilepsy

癫癎患者,尤其是难治性癫癎患者,发生猝死的风险较一般人群要高。癫癎猝死为癫癎患者突然发生非外伤、非溺死的死亡,并排除了癫癎持续状态,尸检未发现造成死亡的器质性或中毒性方面的确切原因。关于癫癎猝死机制的研究集中在癫癎发作可能导致的心律失常和呼吸抑制方面。文中对近年来在癫癎猝死机制中呼吸功能障碍、心脏功能障碍、意识障碍方面,以及分子和基因方面的研究进展进行综述。

The risk of sudden death is higher in epilepsy patients than in general population, especially in patients with refractory epilepsy. Sudden unexpected death in epilepsy （SUDEP） is the sudden, unexpected, non-traumatic, and non-drowning death of a patient with epilepsy, excluding documented status epilepticus, and in which postmortem examination does not reveal a structural or toxicological cause of death. Researches of mechanisms of SUDEP mostly have focused on cardiac arrhythmia and respiratory suppression during and after seizures. The recent SUEDP mechanism research advances in aspects of respiratory dysfunction, cardiac dysfunction, impaired consciousness were reviewed, and genetics and cellular elements as well.