脑钠肽水平在慢性阻塞性肺疾病中的诊断价值

The value of brain natriuretic peptide level in diagnosis of chronic obstructive pulmonary disease

目的:探讨脑钠肽水平在慢性阻塞性肺疾病(COPD)中的诊断价值。方法:选择60例慢性阻塞性肺疾病患者为研究对象,肺动脉高压30例为观察组,无肺动脉高压为30例为对照组,对两组患者的BNP水平及右室内径、收缩末期左室内径、左右室内径比、LVEF值、肺动脉收缩压进行观察。结果:观察组患者的BNP值水平显著较对照组高,差异有统计学意义(P<0.05);观察组的心脏超声心动图指标中,右室内径与右室内径/左室内径、肺动脉压力等指标显著高于对照组,差异有统计学意义(P<0.05);但是两组患者的LVEF值对比差异无统计学意义(P>0.05)。结论:血浆BNP在慢性阻塞性肺疾病的诊断中,是显著的右室扩张及肺动脉高压敏感指标,为临床治疗提供确切依据。

Objective To investigate the diagnostic value of brain natriuretic peptide levels in patients with chronic obstructive pulmonary disease （COPD）. Method 60 cases of chronic obstructive pulmonary disease patients in this study,30 cases of pulmonary hypertension in the observation group,without pulmonary hypertension 30 cases in the control group, for two BNP levels in patients and in patients with right ven- trieular diameter,left ventricular end -systolic diameter,left ventricular diameter ratio, LVEF values, pulmonary artery systolic pressure were observed. Results The group of patients with BNP levels were significantly higher than the control group, the difference was statistically signif- icant （ P 〈 O. 05 ） ; Observation group echocardiography indicators, fight ventricular diameter and right ventricular diameter / left ventricle, pul- monary artery pressure other indicators significantly higher,the difference was statistically significant （P 〈 0. 05 ） ;However LVEF value com- parison groups were not significantly different （ P 〉 0. 05 ）. Conclusion Plasma BNP in the diagnosis of chronic obstructive pulmonary dis- ease,with significant right ventricular dilatation sensitive indicator of pulmonary hypertension agent,provide the exact basis for clinical treat- ment.