聚乙二醇长效干扰素联合利巴韦林抗病毒治疗慢性丙型肝炎疗效观察及不良反应

Peg-IFN combined with repairing for the treatment of chronic hepatitis C virus infection,observation of treatment efficacy and adverse reactions

目的:观察聚乙二醇长效干扰素联合利巴韦林治疗慢性丙型肝炎的疗效、不良反应,以及不良反应对最终疗效的影响。方法:选取接受慢性丙型肝炎的病患84例,将这些病患随机分成两组,治疗组与对照组,每组共有病患42例,为治疗组中的病患提供聚乙二醇长效干扰素联合利巴韦林抗病毒药物,为对照组中的病患提供普通干扰素500万U的安福隆进行皮下注射,对比两组病患的治疗效果与不良反应。结果:经过48周治疗后,治疗组中病患的快速病毒学应答(RVR)、早期病毒学应答(EVR)、治疗结束时病毒学应答(ETVR)、持续病毒学应答(SVR)、无应答及复发率均优于对照组,P<0.05,具有统计学差异意义。结论:临床治疗慢性丙型肝炎时,聚乙二醇长效干扰素联合利巴韦林的治疗效果明显比普通干扰素效果好。

Objective To observe the treatment efficacy, adverse reactions and the effects of adverse reactions on treatment results of Peg -IFN combined with ribavirin for the treatment of chronic hepatitis C. Method 84 patients chronic pneumonia were selected, these pa- tients were randomly divided into two groups,the treatment group and control group, each group a total of 42 patients,the patients in treatment group provided polyethylene glycol peg- interferon plus ribavirin antiviral drugs, the patients in control group proyided ordinary interferon 5 million U subcutaneous injection of interferon, compared the therapeutic effect of two groups of patients with adverse reactions. Results After 48 weeks after treatment,the treatment group patients in the early rapid virological response （RVR）, virological （EVR）, at the end of the treatment virological （ETVR）, sustained virological response （SVR）, no answer, mad recurrence rate were better than control group with sta- tistically significance （P 〈 0. 05 ）. Conclusion Clinical treatment of chronic hepatitis c, polyethylene glycol peg- interferon plus ribavirin treatment effect is significantly better than the common effect of interferon.