腹型肥胖者发生糖尿病的预测因子

The predictor of Diabetes Mellitus in Subjects with Abdominal Obesity

目的:探讨腹型肥胖者发生糖尿病的危险因素。方法:采用病例对照研究,按照腰围身高比选出腹型肥胖人群,分为单纯腹型肥胖组(VO)、腹型肥胖合并2型糖尿病组(VO-DM),检测两组患者的体脂参数、血脂、空腹血糖、空腹C肽及白介素6(IL-6)、高敏C-反应蛋白(hs CRP)水平,采用稳态模式胰岛素抵抗指数(HOMA-IR)评价胰岛素抵抗。采用t检验及logistic多因素回归分析来探讨腹型肥胖者发生糖尿病的危险因素。结果:VO-DM组与VO组比较,年龄、FBG、IL-6、hs CRP、IR水平显著升高,差异有统计学意义(P<0.05)。多元逐步回归分析显示,IL-6是腹型肥胖者发展为糖尿病的独立危险因素。结论:腹型肥胖者IL-6的测定对糖尿病的发生具有重要的预测价值。

Objective To study risk factors of diabetes mellitus in subjects with abdominal obesity. Method The investigation used a case control study. According to the waist to height ratio, visceral obesity subjects were selected. All the subjects were divided into two groups：vis- ceral obesity control subjects （ VO ）, obese diabetic patients （ VO - DM ）. Anthropomctrical parameters, serum lipids, fasting serum glucose and fasting C -peptide, IL- 6 ,hsCRP were measured in two group subjects. Homeostasis model assessment （HOMA） was applied to assess the status of insulin resistance. The risk factors of diabetes in subjects with abdominal obesity were evaluated with t test, multivariate logistic re- gression analysis. Results The levels of age, FBG, IL - 6, hsCRP, IR in patients of group VO - DM were significantly higher than those of group VO （ P 〈 0. 05 ）. Multiple stepwise regression analysis showed that IL - 6 was the independent risk factor for forming diabetes in abdomi- nal visceral obesity subject. Conclusion The detection of IL-6 can predict the forming of diabetes in obese subjects.