低能量1064nm调Q激光联合强脉冲光治疗面部继发性色素沉着的疗效观察

Efficacy of low energy 1064 nm Q-switched laser and intense pulsed light in treatment of facial post-inflammatory hyperpigmentation

目的 探讨低能量1064 nm调Q激光联合强脉冲光（IPL）治疗继发性色素沉着的疗效和可行性.方法 将128例继发性色素沉着患者依据不同治疗方式,完全随机分为低能量1064 nm调Q激光治疗组（42例）,强脉冲光治疗组（40例）,低能量1064 nm调Q激光联合强脉冲光治疗组（46例）.比较3组的治疗效果.结果 通过6次治疗,强脉冲光组和调Q激光组的有效率分别为50.0％（20/40）、52.4％（22/42）,两组治疗结果比较差异无统计学意义（P＞0.05）;低能量1064 nm调Q激光联合强脉冲光疗组有效率为73.9％（34/46）,与强脉冲光和调Q激光治疗组比较,差异有统计学意义（P＜0.05）.结论 低能量1064 nm调Q激光联合强脉冲光是面部继发性色素沉着有效的治疗方法,并且安全无明显不良反应.

Objective To study the feasibility of joint phototherapy in the treatment of post-inflammatory hyperpigmentation and non-drug therapy in clinical popularization value of 1064 nm Qswitched laser in combination with low energy intense pulsed noncoherent light for secondary pigmentation.Methods A total of 128 patients with post-inflammatory hyperpigmentation were randomly divided into 3 groups according to different treatments：first group （42 cases） was subjected to low energy 1064 nm Q-switched laser treatment;second group （40 cases） had intense pulsed light treatment;third group （46 cases） had low energy 1064 nm Q-switched laser plus intense pulsed light therapy.Results After treating for 6 times,the effective rates of intense pulsed light and Q laser were 50％ （20/40） and 52.4％ （22/42）,respectively,without statistical significance between two groups （P＞0.05）.Effective rate of the third group was 73.9％ （34/46）,with significant difference （P＜0.05）,compared with the first two groups.Conclusions For those who refuse any drug treatment,low energy 1064 nm Q-switched laser with intense pulsed light therapy is an effective option to facial postinflammatory hyperpigmentation.Furthermore,it has obvious and safe effect without complications and deserves popularization.