摘要
目的探讨厄贝沙坦对2型糖尿病模型大鼠心肌TGF-β1和CTGF表达的影响。方法对正常大鼠、糖尿病大鼠和厄贝沙坦给药的糖尿病大鼠进行体重、心脏重量指数、血糖和胰岛素的测定和比较,分析其心肌组织中TGF-β1和CTGF的表达。结果两组动物3个月和6个月的体重、心脏重量指数、血糖和胰岛素表达的差异具有统计学意义,P<0.05。厄贝沙坦能够降低干预组TGF-β1和CTGF的表达,且差异具有统计学意义,P<0.05。结论厄贝沙坦对2型糖尿病模型大鼠的心肌组织具有一定的保护作用,值得进一步的探讨和研究。
Objective To explore the influence of irbesartan on the expression of myocardial TGF-β1 and CTGF in type 2 diabetic rats. Methods The blood glucose, insulin, body weight, and heart weight index in type 2 diabetic rats and healthy controls were determined. The expression of myocardium TGF-beta 1 and CTGF in type 2 diabetic rats after treated with irbesartan were analyzed. Results There were significantly difference on body weight, heart weight index, blood glucose and insulin between type 2 diabetic rats with and without irbesartan treatment（P 〈 O. 05）. The expression of TGF-β1 and CTGF in type 2 diabetic rats with irbesartan intervention were statistical lower than that of without irbesartan intervention （ P 〈 0.05 ）. Conclusion Irbesartan could have a protective effect on myocardial tissue of type 2 diabetic rats, and it is worth for further study.
出处
《标记免疫分析与临床》
CAS
2015年第7期669-671,共3页
Labeled Immunoassays and Clinical Medicine
