人类免疫缺陷病毒与深部真菌感染

Human immunodeficiency virus and deep fungal infection

人类免疫缺陷病毒(HIV)感染的发病率与致死率很高,已成为人类健康的一大威胁,其中约50%的HIV感染者最终因侵袭性真菌病而死亡。高效抗反转录病毒治疗(HAART)的应用大大降低了HIV感染者深部真菌病的发生率。因此,深入研究HIV与深部真菌病的关系,对预防、诊断和治疗HIV感染者深部真菌病具有十分重要的意义。本文归纳了HIV感染者深部真菌病的流行病学调查、诊断与治疗进展,有助于临床医师预防和诊治HIV感染者深部真菌病,也为将来新型抗真菌药物的研发提供了思路和方向。

Human immunodeficiency virus （HIV ） is a global threat to health with high morbidity and mortality ,and 50% of all HIV‐related death is associated with invasive fungal infection . Highly active antiretroviral therapy （HAART ） is used to treat HIV infection and can significantly reduce incidence of HIV‐related opportunistic fungal infection .In this article ,the epidemiology ,diagnosis and treatment of HIV‐related fungal infection are reviewed , giving an insight into study of deep fungal infection and a reference for clinic practice .