甲钴胺联合神经节苷酯治疗慢性酒精中毒性周围神经病的临床分析

Clinical analysis of mecobalamin combined with ganglioside in treatment of peripheral neuropathy in chronic alcoholism

目的观察甲钴胺联合单唾液酸四己糖神经节苷酯(神经节苷酯)治疗慢性酒精中毒性周围神经病(CAPN)的临床疗效。方法选取48例确诊为慢性酒精中毒性周围神经病患者,随机分成治疗组和对照组,对照组给予甲钴胺及常规药物治疗,治疗组在此基础上加用神经节苷酯,治疗4周后的临床疗效采用症状体征和神经传导速度进行评价。结果治疗组总有效率为91.7%,对照组总有效率66.7%,治疗组总有效率比对照组高,差异有统计学意义(P<0.05)。两组患者治疗后的正中神经和腓总神经的神经传导速度都有增加,治疗组比对照组增加更明显,差异有统计学意义(P<0.05)。结论甲钴胺联合神经节苷脂治疗慢性酒精中毒性周围神经病变可显著改善患者的症状体征和神经传导速度,值得临床推广应用。

Objective To investigate the clinical efficacy of mecobalamin combined with monosialotetrahexosylganglioside （ganglio- side） in the treatment of peripheral neuropathy in chronic alcoholism. Methods Forty-eight patients who were diagnosed with periph- eral neuropathy in chronic alcoholism were randomly divided into treatment group and control group. The patients in the control group were given mecobalamin and conventional medicine; in addition to the therapy for the control group, ganglioside was added to the pa- tients in the treatment group. Symptoms, signs, and nerve conduction velocity were evaluated for clinical efficacy after 4-week treat- ment. Results The overall response rate was 91.7% for the treatment group and was 66.7% for the control group. The overall re- sponse rate of the treatment group was significantly higher than that of the control group （P 〈 0.05 ）. The nerve conduction velocities of the median nerve and common peroneal nerve increased in the two groups after treatment and the treatment group had a significantly higher increase （P 〈 0.05 ）. Conclusions Mecobalamin combined with ganglioside in the treatment of peripheral neuropathy in chron- ic alcoholism can significantly improve symptoms, signs, and nerve conduction velocity, which indicates that this therapy is worthy of clinical application.