DNA修复基因XRCC1多态性与颅底脑膜瘤易感性关联研究

Association between DNA repair gene XRCC1 polymorphism and susceptibility to skull base meningioma

目的探讨DNA修复基因XRCCl单核苷酸多态性（SNP）与颅底脑膜瘤易感性的关系。方法采用病例．对照研究方法，收集124例颅底脑膜瘤患者和218例健康对照，运用多重单碱基延伸SNP分型（MultiplexSNaPshot）技术检测XRCCl基因rsl799782位点在脑膜瘤组和对照组中的分布情况。结果XRCClrsl799782位点中CT基因型携带者患颅底脑膜瘤的风险降低（OR=0．606，95％CI：0．374～0．982，P：0．041）。在颅底脑膜瘤组中，≥50岁组相比〈50岁组的个体，其发病风险降低（OR=0．4160，95％CI=0．201～0．862）。XRCCl基因rsl799782多态性与颅底脑膜瘤的生长部位、瘤周水肿、骨质破坏及硬膜侵袭之间不存在关联性（P〉0．05）。结论XRCCl基因rsl799782位点CT基因型携带者可降低颅底脑膜瘤发病风险，rsl799782多态位点可能与颅底脑膜瘤发病风险相关，相对低龄患者更容易发病，但仍需大样本量的颅底脑膜瘤流行病学研究加以证实。

Objective To investigate the association between the single nucleotide polymorphism （SNP） in XRCC1 gene and the sus- ceptibility to skull base meningioma. Methods A total of 124 patients with skull base meningioma and 218 healthy controls were col- lected for this case-control study. The genotype distributions of XRCC1 SNP rs1799782 in the two groups were determined by Multiplex SNaPshot. Results The carriers of CT genotype in XRCC1 rs1799782 had a lower risk of skull base meningioma than others （ OR = 0.606, 95% CI ： 0.374 - 0. 982, P = 0. 041 ）. In the skull base meningioma group, the individuals I〉50 years of age had a lower risk of skull base meningioma than those 〈 50 years of age （ OR = 0. 416, 95% CI ： 0.201 - 0. 862, P = 0. 017）. XRCC1 rs1799782 poly- morphism was not associated with tumor location, peritumoral edema, bone destruction, and dural invasion （P 〉0.05 ）. Conclusions The carriers of CT genotype in XRCC1 rs1799782 have a lower risk of skull base meningioma. XRCC1 rs1799782 poly- morphism may be associated with the risk of skull base meningioma. The younger patients have a higher susceptibility to skull base meningioma. However, these results need to be confirmed in epidemiological studies with larger samples.