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核转录相关因子2—抗氧化反应元件信号通路在认知障碍相关疾病中的作用 被引量：2

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摘要 核转录相关因子2-抗氧化反应元件(Nrf2-ARE)信号通路是机体内最重要的抗氧化应激通路之一。近年来研究发现,在血管性痴呆、阿尔兹海默病、帕金森病等认知障碍相关的疾病中,机体可以通过激活Nrf2-ARE信号通路来增加内源性的抗氧化能力,最终使认知功能得到改善。因此,本文旨在对Nrf2-ARE信号通路的组成、调节及其与认知障碍相关疾病的关系作一综述。
作者 齐倩倩 吕佩源
机构地区 河北医科大学研究生学院 河北省人民医院神经内科
出处 《国际神经病学神经外科学杂志》 北大核心 2015年第2期173-177,共5页 Journal of International Neurology and Neurosurgery
基金 河北省自然科学基金(H2013307046) 河北省重大医学科研课题项目(zd2013005)
关键词 核转录相关因子2-抗氧化反应元件信号通路 氧化应激 认知障碍
分类号 R749.1 [医药卫生—神经病学与精神病学]
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参考文献38

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共引文献24

同被引文献48

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国际神经病学神经外科学杂志
2015年 第2期

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