原发性视网膜色素变性患者五种血清离子浓度的变化

Changes of serum concentration of five ions in patients with primary retinitis pigmentosa

目的分析原发性视网膜色素变性(primary retinitis pigmentosa,PRP)患者血清中镁、钙、钾、钠及氯离子浓度的变化情况。设计回顾性病例系列。研究对象 2013年4月至2014年4月于北京同仁医院就诊的PRP患者82例,同期体检中心正常个体99例。方法取患者静脉血,按临床常规血清检测技术,测量PRP患者血清中镁、钙、钾、钠及氯离子的浓度,并按疾病严重程度对PRP进行临床分期,通过与正常对照组的比较,分析PRP患者血清中五种离子浓度的变化情况。主要指标血清镁、钙、钾、钠及氯离子浓度。结果与正常组(0.874±0.076 mmol/L)相比,PRP患者血清镁离子浓度(0.845±0.067 mmol/L)明显降低(t=-2.688,P=0.008);而钙离子浓度(PRP患者:2.331±0.086 mmol/L,正常组:2.225±0.092mmol/L)和钾离子浓度(PRP患者:4.104±0.347 mmol/L,正常组:3.897±0.310 mmol/L)明显升高(t=5.672、4.225;P=0.000、0.000)。与正常组相比,早期PRP患者血清中,镁离子浓度(0.830±0.070 mmol/L)明显较低(P=0.001),而钙离子浓度(2.325±0.087 mmol/L)和钾离子浓度(4.040±0.265 mmol/L)明显较高(P=0.000,0.017)。与正常组相比,晚期患者血清中,钙离子浓度(2.337±0.086 mmol/L)和钾离子浓度(4.174±0.411mmol/L)明显较高(P=0.000、0.000)。早期患者血清镁离子浓度较晚期患者明显较低(P=0.044)。结论 PRP患者血清镁、钙、钾离子浓度明显异于正常组,其可能与PRP发病有关。

Objective To study concentration changes of serum magnesium, calcium, potassium, sodium and chloride ions in patients of primary retinitis pigmentosa （PRP）. Design Retrospective case series. Participants 82 PRP patients and 99 normal control cases were enrolled from April 2013 to April 2014. Methods Patients with PRP were divided into four phases according to the severity of disease. The serum levels of magnesium, calcium, potassium, sodium and chloride were measured, and compared with that of con- trol groups. Main Outcome Measures Serum levels of magnesium, calcium, potassium, sodium and chloride ions. Results Compared with normal group, the concentration of magnesium （0.845±0.067 mmol/L） was significantly lower than the normal group （0.874±0.076 mmoYL） （t=-2.688, P=0.008）, but the levels of calcium （2.331±0.086 mmol/L vs 2.225±0.092 mmol/L） （t=5.672, P=0.000） and potas- sium （4.104±0.347mmol/L vs 3.897±0.310 mmol/L） （t=-4.225, P=-0.000） were significantly higher. Furthermore, it has been found that compared with normal group, in early phase of PRP, the magnesium （0.830±0.070 mmoYL）（P=0.001） was significantly lower, but the calcium （2.325±0.087 mmol/L） （P=-0.000） and potassium （4.040±0.265 mmol/L）（P=-0.017） were significantly higher. In late phase of PRP, the calcium （2.337±0.086 mmol/L） （P=-0.000） and potassium （4.174±0.411 mmol/L） （P=0.000） were also significantly higher than that in normal group. Interestingly, the magnesium in late phase of PRP was significantly higher than that in early PRP （P=-0.044）. Conclusion In patients with PRP, the serum levels of magnesium, calcium and potassium are shown the changes, which probably re- lated with occurrence of PRP.