平阳霉素注射治疗血管瘤致过敏性休克总结

Summary of pingyangmycin injection treatment for hemangioma result in anaphylactic shock

目的:总结分析平阳霉素注射治疗血管瘤病例中过敏性休克病例,为临床预防和减少过敏性休克发生提供参考。方法:通过回顾性分析我院1991年至2012年6 029例平阳霉素注射治疗血管瘤病例中发生过敏性休克患者的临床病例资料。结果:过敏性休克多发生于注射治疗后10 min内,门诊注射后观察30 min后离院,可有效避免严重过敏性休克;注射前静推地塞米松可降低过敏性休克的发生,增加疗效;多次注射易发生过敏性休克(发生率约0.83‰),过敏性休克患者血清特异性Ig E均阳性、总免疫球蛋白E(Ig E)均明显增高。结论:平阳霉素多次注射可因变应原累及致敏作用而发生过敏性休克,但其发生率极低且可控。

Objective： The purpose is to summarize and analyze the anaphylactic shock cases in pingyangmycin injection therapy of hemangioma,in order to provide reference for preventing and reducing the anaphylactic shock in clinic. Methods： The method is to retrospectively analyze the data of the patients subjected to the anaphylactic shock in 6029 clinical cases in our hospital about injecting the pingyangmycin to treat hemangioma from 1991 to 2012. Results： The anaphylactic shock usually occurs within 10 minutes after the injection therapy,so the patient with such anaphylactic shock should get the injection treatment in out-patient department and remain in hospital under observation and can leave 30 minutes later,and therefore,severe anaphylactic shock can be effectively avoided. Before injection,dexamethasone should be subjected to intravenous injection in order to reduce the adverse effect as well as improving the treatment effect. Multi-injection might cause anaphylactic shock（ about 0. 83% occurrence rate）. The serologicalspecificity Ig E of the patient subjected to the anaphylactic shock is positive,and the whole immune globulin E（ Ig E） obviously increased. Conclusion： Injecting the pingyangmycinat many times might cause allergen accumulative sensitization effect,resulting in the anaphylactic shock; however,the anaphylactic shock is relatively low in occurrence rate and is controllable.