慢性阻塞性肺疾病合并意识障碍患者血清IFN-γ、IL-1β、NO水平变化的临床意义

The clinical significance for changes of serum IFN-γ,IL-1β and NO in patients with chronic obstructive pulmonary disease merging conscious disturbance

目的:探讨干扰素γ(IFN-γ)、白介素1β(IL-1β)及一氧化氮(NO)在慢性阻塞性肺疾病(COPD)合并意识障碍中的水平变化及其临床意义。方法:60例COPD合并意识障碍患者作为治疗组,以30例健康体检者为对照组,治疗组予以抗炎,止咳平喘等常规治疗,对照组不作处理。以ELISA法测定对照组及治疗组治疗前后的IFN-γ、IL-1β水平,以硝酸还原酶法检测NO水平;测定对照组及治疗组治疗前后动脉血气指标、格拉斯哥评分(GCS)。结果:治疗组治疗前IFN-γ、IL-1β、NO水平显著高于对照组和治疗后组(P<0.05),其动脉血气指标、GCS评分与对照组和治疗后组比较有显著差异(P<0.05)。结论:IFN-γ、IL-1β作为细胞炎症因子可能参与了COPD合并意识障碍的发生发展,降低IFN-γ、IL-1β水平可以下调NO水平,缓解患者的病情,为该病的治疗提供了重要的理论依据。

Objective： To investigate the change and clinical meaning of serum IFN-γ,IL-1β and NO in patients with chronic obstructive pulmonary disease（ COPD） merging conscious disturbance. Methods： 98 patients with COPD merging conscious disturbance were regarded as control group. 20 healthy examined people were as normal group. Control group was given anti-inflammatory and relieving cough and asthma therapy. Thus normal group were not treated. Level of serum NO,IFN-γ,IL-1β in each group were tested by ELISA. Arterial blood gas and GCS were also checked. Results： Compared with normal group and non-treatment group,arterial blood gas and GCS of treated group had a significant difference（ P 〈 0. 05）. Level of serum IFN-γ,IL-1β and NO in treated group were greatly higher than that of normal group and non-treatment group（ P 〈 0. 05）. Conclusion： As the cell inflammation factor,IFN-γ and IL-1βmay be associated with occurrence and progression of COPD merging conscious disturbance. However the patient’s condition can be released by decreasing level of serum IFN-γ,IL-1β and NO. It offers an important theoretical foundation on therapy for this disease.