胰岛素样生长因子ⅡmRNA结合蛋白—3(IMP3)在妇科肿瘤中的应用

The application of insulin-like growth factor Ⅱ mRNA binding protein 3( IMP3) in gynecological tumors

胰岛素样生长因子ⅡmRNA结合蛋白3(insulin-like growth factorⅡmRNA binding protein 3,IMP3或IGF2BP3或KH-domain containing protein,KOC,又名L523S)是胰岛素样生长因子RNA结合蛋白家族中的一员,主要表达于发育中的胚胎上皮组织、肌肉和胎盘中,但随着组织分化成熟,表达逐渐下降,在成人组织中仅有极微量的表达。近来研究发现,IMP3在多种恶性肿瘤中表达升高,且与其恶性程度、浸润、转移、预后等密切相关,可能是恶性上皮性肿瘤的生物标志物。本文就目前IMP3在妇科肿瘤的研究进展作一综述。

The Insulin-line growth factor Ⅱ mRNA binding protein 3 is one the the members in Insulin-like growth factor RNA binding protein family. The expression of IMP3（ Insulin-like growth factor Ⅱ mRNA binding protein 3） plays an important role in cell growth,organogenesis and in the process of embryos formation,and with the mature of organization,it shows a little in adult tissues,IMP3 was found in a variety of malignant tumors,and it has been strongly associated with malignant degree,invasion,metastasis and prognosis. It might be a biomarker of some malignant epithelial tumors. This paper is a review about IMP3 application in the diagnosis and treatment of gynecological tumor.