动脉粥样硬化中DNA甲基化与微小RNA的相互作用

The Interaction Between DNA Methylation and Micro RNA in Atherosclerosis

动脉粥样硬化是心脑血管病的重要发病机制,能侵袭全身血管,其发病机制至今尚未完全阐明。DNA甲基化和微小RNA都属于表观遗传的重要内容,两者在动脉粥样硬化中都有重要作用。目前在动脉粥样硬化中已发现多种微小RNA出现异常表达,可能受甲基化的调节。DNA甲基化可以通过对微小RNA启动子区Cp G岛的甲基化修饰,直接调控微小RNA的表达;或通过改变转录因子甲基化状态,间接调节与其相关的微小RNA表达。微小RNA也可以通过调节甲基转移酶的表达进而调节DNA甲基化。两者相互调节机制构成了基因表达的复杂网络,为动脉粥样硬化发病的分子机制研究提供了新思路。

Atherosclerosis （As） is an important pathogenesis of eardio-cerebrovascular disease, and can affect the whole body blood vessels. Its pathogenesis is not yet fully elucidated. DNA methylation and micro RNA （miRNA） are important parts of the epigenetic, and everyone plays an important role in the As. At present the abnormal expression of a variety of miRNA has been found, which may be adjusted by methylation in the As. DNA methylation can directly regu- late the expression of miRNA by changing the methylation modification of miRNA＇ s promoter CpG island. Also, DNA methylation can indirectly adjust with related miRNA＇ s expression by altering the methylation status of transcription factors. MicroRNA can also adjust the expression of DNA methytransferase （DNMT） and regulate DNA methylation. Regulating mechanism between the two constitutes the complex network of gene expression, which provides a new way of thinking for the molecular mechanism of pathogenesis of As.