期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

家族性高胆固醇血症的临床与基因治疗新进展 被引量：8

Recent Developments in the Clinical and Genetic Treatments of Familial Hypercholesterolemia
下载PDF
导出
摘要 家族性高胆固醇血症(FH)是一种常染色体显性遗传病,临床表现为血浆总胆固醇和低密度脂蛋白胆固醇水平升高、皮肤或肌腱黄色瘤和早发冠心病。FH的治疗手段主要包括临床治疗和基因治疗,近年来新药的研发和基因研究的快速发展为FH的治疗提供了更多的手段,本文将对FH的临床和基因治疗的新进展进行综述。 Familial hypercholesterolemia is an autosomally dominant disease and clinically characterized by elevated serum levels of total and low density lipoprotein cholesterol, the presence of tendon xanthomas and premature coronary ar- tery disease. Clinical and genetic therapies are .the main treatments of familial hypercholesterolemia. Several drugs and genetic research are emerging to help improve the treatments of this disease in recent years. In this review, we will pres- ent the recent developments in the clinical and genetic treatments of familial hypercholesterolemia.
作者 王蓓 林玲
机构地区 广州医科大学研究生学院 海南省第三人民医院心内科
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2014年第12期1287-1291,共5页 Chinese Journal of Arteriosclerosis
关键词 家族性高胆固醇血症 临床治疗 基因治疗 Familial Hypercholesterolemia Clinical Therapy Genetic Therapy
分类号 R596.2 [医药卫生—内科学] R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献33

  • 1李燕,杨毅宁.家族性高胆固醇血症与早发冠心病研究进展[J].中国循证心血管医学杂志,2011,3(4):302-304. 被引量：13
  • 2王绿娅.早发动脉粥样硬化——家族性高胆固醇血症的基础与临床研究[J].中国动脉硬化杂志,2009,17(7):571-572. 被引量：9
  • 3Nordestgaard B, Chapman M, Humphries S, et al. Familial hyper- cholesterolemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart dis- ease. Consensus Statement of the European Atheroosclerosis Society [J]. Euro Heart, 2013, 34(45) : 3 478-490.
  • 4Mariko Harada-Shiba M, Arai H, Oikawa S, et al. Guidelines for the management of familial hypercholesterolemia [ J ]. Atheroscler Thromb, 2012, 19(12) : 1 043-060.
  • 5Yamashita S, Hbujo H, Arai H, et al. Long-term probucol treat- ment prevents secondary cardiovascular events : a cohort study of pa- tients with heterozygous familial hypercholesterolemia in Japan [ J ]. J Atheroscler Thromb, 2008, 15(6): 292-301.
  • 6Watts GF, Gidding S, Wierzbicki AS, et al. Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation[ J]. J Clin Lipidol, 2014,8 (2) : 148-172.
  • 7Dixon Dave L , Sisson Evan M , Butler Michael, et al. Lomitapide and Mipomersen:Novel Lipid-Lowering Agents for the Management of Familial Hypercholesterolemia[J]. J Cardiovas Nurs, 2014, 29 (5) :E7-E12.
  • 8Paul E. Ziajka. Management of Patients With Homozygous Familial Hypercholesterolemia[ R]. And Managed Care, 2013, 19 ( 13 ) : $251 -$256.
  • 9靳松,李春杏,朱珠.治疗家族性高胆固醇血症新药--洛美他派[J].中国药学杂志,2013,48(22):1972-1974. 被引量：4
  • 10Lyseng-Willliamson, Katherine A, Perry, et al. Lomitapide : a guide to its use in adults with homozygous familial hypercholester- olemia in the EU [J]. Drugs And Therapy Perspectives, 2013, 29(12) : 373-378.

二级参考文献68

  • 1王绿娅,蔺洁,刘舒,陈保生.家族性高胆固醇血症样表型遗传异质性的分子基础[J].Acta Genetica Sinica,2005,32(7):770-777. 被引量：14
  • 2陈保生,李德岭,任渝棠.越低越好,越快越好?——他汀类药物强化降脂利弊谈[J].中国动脉硬化杂志,2006,14(9):737-740. 被引量：3
  • 3Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors [ J ]. Cell, 2006, 126(4) : 663-676.
  • 4Hanna J, Wemig M, Markoulaki S, et al. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin [ J ]. Science, 2007, 318 (5 858) : 1 920-923.
  • 5Sullivan GJ, Hay DC, Park IH, et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells [ J ]. Hepatology, 2010, 51 (1): 329-335.
  • 6Tanra D, Noguchi M, Sone M, et al. Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells [ J ]. FEBS Lett, 2009, 583 ( 6 ) : 1 029-033.
  • 7Kuzmenkin A, Liang H, Xu G, et al. Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro [ J]. FASEB J, 2009, 23 (12) : 4 168-180.
  • 8Osakada F, Jin ZB, Hirami Y, et al. In vitro differentiation of retinal ceUs from human pluripotcnt stem cells by smaU-moleculc induction [J].J Cell Sci, 2009, 122 (Pt 17) : 3 169-179.
  • 9Dimos JT, Rodolfa KT, Niakan KK, et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons [J]. Science, 2008, 321 (5 893): 1 218-221.
  • 10Boland MJ, Hazen JL, Nazor KL, et al. Adult mice generated from induced pluripotent stem cells [J]. Nature, 2009, 461 (7 260) : 91-94.

共引文献27

同被引文献76

  • 1郭军华,黄烽,罗渝昆,唐杰.健康志愿者和职业运动员跟腱及其肌腱端的高频超声表现[J].中国医学影像技术,2005,21(8):1262-1265. 被引量：2
  • 2赵水平.家族性混合型高脂血症[J].中国动脉硬化杂志,1996,4(4):304-307. 被引量：3
  • 3中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-419. 被引量：5215
  • 4Beason DP, Hsu JE, Marshall SM, et al. Hypercholesterolemia increases supraspinatus tendon stiffness and elastic modulus across multiple species. J Shoulder Elbow Surg, 2013, 22: 681-686.
  • 5Terasaki F, Morita H, Harada-Shiba M, et al. Familial hypercholesterolemia with multiple large tendinous xanthomas and advanced coronary artery atherosclerosis. Intern Med, 2013, 52: 577- 581.
  • 6Turan A, Teher MA, Yakut ZI, et al. Sonoelastographle assessment of the age-related changes of the Achilles tendon. Med Ultrason, 2015, 17: 58-61.
  • 7Ebeling T, Farln P, Pyorala K. Ultrasonography in the detection of Achilles tendon xanthomata in heterozygous familial hypercholesterolemia. Athcrosclerosis, 1992, 97: 217-228.
  • 8Harada-Shiba M, Arai I4, Oikawa S, et al. Guidelines for the management of familial hypercholesterolaemia. J Atheroscler Thromb, 2012, 19 : 1043-1060.
  • 9Reichwaldt I, Zustin J, Wenke K, et al. Differential diagnosis of tendon tumors: xanthomas caused by hyperlipidemia in children. J Pediatr Surg, 2010, 45: E9-E12.
  • 10Grewal N, Thornton GM, Behzad H, et al. Accumulation of oxidized LDL in the tendon tissues of C57BL/6 or apolipoprotein E knock-out mice that consume a high fat diet: potential impact on tendon health. PLoS One, 2014, 9: e1 14214.

引证文献8

二级引证文献7

中国动脉硬化杂志
2014年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部