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识别慢性肾脏病患者预后不良的最佳肾小球滤过标志物

What is the best glomerular filtration marker to identify people with chronic kidney disease most likely to have poor outcomes？
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摘要 背景 肾小球滤过率（Glomerular filtration rate，GFR）是公认的最佳评价肾功能的指标。近年来，由于GFR成为了国际肾脏疾病分期系统的重要指标1，日益受到关注。便于临床应用的eGFR提高了慢性肾脏病（Chronic kidney disease，CKD）的诊断率2,3，但单独应用估计GFR（eGFR）却不能很好判断患者的预后。
作者 E J Lamb consultant clinical scientist consultant nephrologist J J Deeks professor of biostatistics 余芳芳 张路霞
机构地区 Clinical Biochemistry Kent Kidney CareCentre Test Evaluation Research Group 贵州省人民医院肾内科 北京大学第一医院肾内科 北京大学肾脏病研究所卫生部重点实验室教育部慢性肾脏病防治重点实验室
出处 《英国医学杂志中文版》 2015年第6期346-348,共3页 The BMJ Chinese Edition
关键词 肾小球 肾脏病 滤过 慢性
分类号 S856.59 [农业科学—临床兽医学] S948 [农业科学—水产养殖]
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参考文献28

  • 1Kidney Disease Improving Global Outcomes. Clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Iat 2013 ;3 ( suppl. ) : 1-150.
  • 2Levin A, Stevens PE. Early detection of CKD: the benefits, limitations and effects on prognosis. Nat Rev Nephrol 2011 ;7:446-57.
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  • 5Earley A, Miskulin D, Lamb EJ, Levey AS, Uhlig K. Estimating equations for glomendar filtration rate in the era of creatinine standardizatiou: a systematic review. Ann Intern Med 2012;156:785-95.
  • 6Johnson DW, Jones GR, Mathew TH, Ludlow M J, Doogue MP, Jose MD, et al. Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: new developments and revised recommendations. Med J Aust 2012 ; 197:224-5.
  • 7National Institute for Health and Care Excellence. Chronic kidney disease: early identification and management of chronic kidney disease in adults in primary and secondary care. NICE, 2014 (available at www. nice. org. uk/guidance/cg182).
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英国医学杂志中文版
2015年 第6期

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