数字化眼动仪对先天性特发性眼球震颤手术疗效的定量评估

Quantitative assess the efficacy of congenital idiopathic nystagmus surgery by digital eye tracker

目的 评估数字化眼动仪在先天性特发性眼球震颤（CIN）手术疗效判定中的可行性.方法 采用自身配对设计对16例CIN患者进行数字化眼动仪检测的前瞻性研究,记录患者数字化眼动仪检测的相对静止区以及手术前后各偏转角度注视下的眼球震颤的频率、振幅、震强,用相关分析判断数字化眼动仪检测与临床观察之间相对静止区的一致性,配对样本t检验判断个体手术前后水平方向水平、垂直眼球震强的改善情况,并对左右侧25°内的间隔5°的各注视点手术前后相应位点的震强进行比较,记录各注视点改善的位点数.结果 数字化眼动仪检测判定和临床观察之间的相对静止区一致性高（r=0.952,P＜0.01）;16例CIN患者中有9例手术前后水平震强改善（t=2.335～6.609,P＜0.05）,5例患者手术前后垂直震强改善（t=2.176～5.471,P＜0.05）;手术前后水平方向67.63％（117/173）的注视点水平震强得到改善,69.94％（121/173）的注视点的垂直震强得到改善.结论 自行研制的数字化眼动仪能有效进行CIN患者手术前后眼球震颤的检测和定量评估手术疗效.

Objective To evaluate the feasibility of independently developed digital eye tracker in determining the efficacy of congenital idiopathic nystagmus （CIN） surgery.Methods Aprospective selfpairing study.The surgical efficacy was evaluated by independently developed eye tracker in 16 CIN patients.The null zone and the frequency,amplitude,intensity of nystagmus in various gazing position were recorded with eye tracker pre and post operatively.The consistency of null zone determined by digital eye tracker and clinical investigation were evaluated.The preoperative and postoperative rectification of horizontal and vertical nystagmus in the horizontal direction of individual patient were compared by paired samples t-test.The improvement or aggravation quantity were recorded by comparing preoperative and postoperative intensity of nystagmus every 5°within 25°.Result The null zone got from digital eye tracker and clinical investigation were highly consistent （r=0.952,P〈0.01）.The horizontal and vertical intensity improved in 9 patients （t=2.335-6.609,P〈0.05） and 5 patients （t=2.176-5.471,P〈0.05） respectively after surgery.There were 67.63% （117/173） horizontal intensity and 69.94% （121/173） vertical intensity improvement.Conclusion The independently developed digital eye tracker can quantitatively evaluate the pre and post-operative nystagmus and analyze the surgical efficacy for CIN patients.