成人先天性胆管扩张症合并急性胰腺炎的危险因素分析

Related risk factors of acute pancreatitis followed by adult congenital biliary dilatation

目的:探讨成人先天性胆管扩张症(CBD)合并急性胰腺炎(AP)的危险因素。方法:回顾性分析2002年2月至2014年4月我院收治的96例成人CBD患者,分为CBD合并AP组(AP组)和CBD不合并AP组(NAP组),通过单因素分析和logistic回归分析成人CBD合并AP的危险因素。结果:单因素分析显示,胆管结石、谷丙转氨酶(ALT)和谷草转氨酶(AST)与AP的发生有相关性(P<0.05),logistic回归分析显示胆管结石是CBD并发AP的独立危险因素(P<0.05)。设CBD合并胆管结石为A组(大结石为A1组,小结石为A2组),单纯胆管结石为B组(大结石为B1组,小结石为B2组),A2组AP发病率最高,显著高于B2组和A1组,差异有统计学意义(均P<0.05)。结论:胆管小结石是CBD合并AP的危险因素。

Objective： To identify the potential risk factors of congenital biliary dilatation（CBD） complicated with acute pancreatitis（AP） in adults. Methods： A total number of 96 patients that diagnosed as CBD in our hospital from February 2002 to April 2014 were retrospectively reviewed, which were divided into two groups, CBD with AP（AP group） and CBD without AP（NAP group）. Univariate and multivariate Logistic analysis were conducted to evaluate risk factors complicated with AP. Results： In univariate analysis, significant differences were found between these two groups by biliary calculi, ALT, AST（P〈0.05）. In logistic regression analysis, only biliary calculi was recognized as the significative factor（P〈0.05）. CBD combined bile duct stones of group A（Merge large stones A1 group, Merge small stones A2 group）; Simple biliary calculi as control group B（large stones B1 group, small stone B2 group）. Incidence of acute pancreatitis in A2 group is highest and is significantly higher than that of B2 group and A1 group（P〈0.05）. Conclusion： Biliary small stones with adult CBD in patients is a risk factor of AP.