益生菌治疗变应性鼻炎的研究现状

The research status of probiotic treatment of allergic rhinitis

变应性鼻炎（allergic rhinitis,AR）是鼻科的常见病之一,是易感个体接触变应原后,由免疫球蛋白E（IgE）介导的变态反应性疾病。随着全球气候变暖、空气污染等诸多因素的影响,AR的患病率大大提高〔1〕。AR的患病人群以儿童及青壮年为主,男女性别比例无明显差异,常因不能彻底治愈导致病情反复、难控制,严重者可并发支气管哮喘、过敏性咽喉炎、结膜炎及分泌性中耳炎等疾病。

Allergic rhinitis is nasal mucosa of immediate hypersensitivity,and the current treatment is not satisfied.With the increasing incidence in recent years,we pay more attention on the effective treatments.There are some published studies indicate the benefit of probiotic for allergic rhinitis.Refer to the related literature in recent years,the paper will discuss probiotic species,safety,route of administration,mechanism and efficacy,pointing out a new direction for the treatment of allergic rhinitis.