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肠促胰素分泌分子机制的研究进展 被引量：4

Molecular mechanisms of incretin hormone secretion
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摘要 肠促胰素是由肠上皮内分泌细胞分泌的一类肠源性激素.已有大量研究去探索肠促胰素分泌的分子机制,包括葡萄糖、脂质、蛋白质等营养素对肠道内分泌细胞的促分泌作用.本文将对影响肠促胰素分泌的相关感应信号通路研究进展作一综述. Incretin is a kind of intestinal hormone secreted by the enteroendocrine cells in the intestinal epithelium.There has been plenty of research to explore the molecular mechanisms of incretin hormone secretion,including secretionpromoting factors such as glucose,lipid,protein and other nutrients in enteroendocrine cells.This review aims to discuss the signal pathways related to incretin hormone secretion.
作者 刘剑 吴明昊 高宇
机构地区 承德医学院研究生学院 承德医学院附属医院内分泌科
出处 《世界华人消化杂志》 CAS 2015年第16期2582-2587,共6页 World Chinese Journal of Digestology
关键词 肠促胰素 分子机制 2型糖尿病 营养素信号 Incretin Molecular mechanisms Type 2 diabetes mellitus Nutrient signaling
分类号 R587.1 [医药卫生—内分泌] R589.2 [医药卫生—内分泌]
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参考文献50

  • 1Pannacciulli N,Le DS,Salbe AD,Chen K,Reiman EM,Tataranni PA,Krakoff J.Postprandial glucagon-like peptide-1 (GLP-1) response is positively associated with changes in neuronal activity of brain areas implicated in satiety and food intake regulation in humans.Neuroimage,2007,35:511-517.
  • 2Vilsb?ll T,Christensen M,Junker AE,Knop FK,Gluud LL.Effects of glucagon-like peptide-1 receptor agonists on weight loss:systematic review and meta-analyses of randomised controlled trials.BMJ,2012,344:d7771.
  • 3Baggio LL,Drucker DJ.Biology of incretins:GLP-1 and GIP.Gastroenterology,2007,132:2131-2157.
  • 4Koliaki C,Doupis J.Incretin-based therapy:a powerful and promising weapon in the treatment of type,2 diabetes mellitus.Diabetes Ther,2011,2:101-121.
  • 5Buse JB,Nauck M,Forst T,Sheu WH,Shenouda SK,Heilmann CR,Hoogwerf BJ,Gao A,Boardman MK,Fineman M,Porter L,Schernthaner G.Exenatide once weekly versus liraglutide once daily in patients with type,2 diabetes (DURATION-6):a randomised,open-label study.Lancet,2013,381:117-124.
  • 6Nauck MA,Vardarli I,Deacon CF,Holst JJ,Meier JJ.Secretion of glucagon-like peptide-1 (GLP-1) in type,2 diabetes:what is up,what is down? Diabetologia,2011,54:10-18.
  • 7Reimann F.Molecular mechanisms underlying nutrient detection by incretin-secreting cells.Int Dairy J,2010,20:236-242.
  • 8Reimer RA.Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion,in the human NCI-H716 enteroendocrine cell line,is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases.J Endocrinol,2006,191:159-170.
  • 9Ezcurra M,Reimann F,Gribble FM,Emery E.Molecular mechanisms of incretin hormone secretion.Curr Opin Pharmacol,2013,13:922-927.
  • 10Parker HE,Reimann F,Gribble FM.Molecular mechanisms underlying nutrient-stimulated incretin secretion.Expert Rev Mol Med,2010,12:e1.

同被引文献66

  • 1Elrick H, Stimmler L, Hlad CJ, Arai Y. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab 1964; 24: 1076-1082.
  • 2Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007; 87: 1409-1439.
  • 3Shiraki A, Oyama J, Komoda H, Asaka M, Komatsu A, Sakuma M, Kodama K, Sakamoto Y, Kotooka N, Hirase T, Node K. The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells. Atherosclerosis 2012; 221: 375-382.
  • 4Hendarto H, Inoguchi T, Maeda Y, Ikeda N, Zheng J, Takei R, Yokomizo H, Hirata E, Sonoda N, Takayanagi R. GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases. Metabolism 2012; 61: 1422-1434.
  • 5Shimoda M, Kanda Y, Hamamoto S, Tawaramoto K, Hashiramoto M, Matsuki M, Kaku K. The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes. Diabetologia 2011; 54: 1098-1108.
  • 6Drucker DJ, Mojsov S, Habener JF. Cell-specific post-translational processing of preproglucagon expressed from a metallothionein-glucagon fusion gene. J Biol Chem 1986; 261: 9637-9643.
  • 7Orskov C, Holst JJ, Knuhtsen S, Baldissera FG, Poulsen SS, Nielsen OV. Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology 1986; 119: 1467-1475.
  • 8van Delft J, Uttenthal LO, Hermida OG, Fontela T, Ghiglione M. Identification of amidated forms of GLP-1 in rat tissues using a highly sensitive radioimmunoassay. Regul Pept 1997; 70: 191-198.
  • 9Orskov C, Rabenh?j L, Wettergren A, Kofod H, Holst JJ. Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes 1994; 43: 535-539.
  • 10Holst JJ, Bersani M, Johnsen AH, Kofod H, Hartmann B, Orskov C. Proglucagon processing in porcine and human pancreas. J Biol Chem 1994; 269: 18827-18833.

引证文献4

二级引证文献8

世界华人消化杂志
2015年 第16期

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