佩尔地平对垂体后叶素诱发腹腔镜子宫肌瘤剔除术患者心血管反应的影响

Effect of perdipine on pituitrin-induced cardiovascular responses in patients undergoing laparoscopic myomectomy

目的探讨不同剂量佩尔地平对垂体后叶素诱发腹腔镜子宫肌瘤剔除术患者心血管反应的影响。方法择期行腹腔镜子宫肌瘤剔除术的患者60例,随机均分为四组。子宫肌瘤剔除前在腹腔镜监视下沿肌瘤周围肌层注入垂体后叶素6U,2min后,P1、P2、P3组分别静脉注射佩尔地平3、5、7μg/kg,C组静脉注射生理盐水5ml作为对照。记录注射垂体后叶素前1min(T0)、用药后30s(T1)、1min(T2)、2min(T3)、5min(T4)和25min(T5)时患者的MAP和HR。结果与T0时比较,T1、T2时四组MAP均降低,HR增快(P<0.05),T4、T5时C组MAP升高,HR减慢(P<0.05)。T4、T5时P1、P2、P3组MAP均低于C组,HR高于C组(P<0.05),且P1、P2组MAP高于P3组,HR低于P3组(P<0.05)。P1、P2、P3组发生低血压的例数分别为0、1、3例。结论静脉注射佩尔地平3μg/kg能有效预防局部注射垂体后叶素诱发腹腔镜子宫肌瘤剔除术患者的BP增高和HR减慢反应。

Objective To study the effect of perdipine on pituitrin‐induced cardiovascular responses in the patients undergoing laparoscopic myomectomy .Methods Sixty patients undergoing laparoscopic myomectomy under general anesthesia were equally and randomly divided into 4 groups . Pituitrin 6 U in normal saline 20 ml was injected around hysteromyoma .Two minutes later ,perdipine 3 ,5 ,7 μg/kg and normal saline 5 ml were injected intravenously in groups of P1 ,P2 ,P3 and C , respectively .The mean arterial blood pressure（MAP） and heart rate（HR） were recorded at 1 minute before（T0） and 30 seconds（T1） ,1 minute（T2） ,2 minutes（T3） ,5 minutes（T4） and 25 minutes（T5） after injection of pituitrin .Results Compared with T0 ,MAP was decreased and HR was increased in 4 groups at T1 and T2 ,while MAP was increased and HR was decreased in group C（P〈0 .05） .MAP was lower and HR was faster in groups of P1 ,P2 and P3 than those in group C ,and MAP was higher and HR was slower in groups of P1 and P2 than those in group P3 at T4 and T5（P〈0 .05） .The case number with hypotension in groups of P1 ,P2 and P3 were 0 ,1 and 3 ,respectively .Conclusion Intravenous injectin of perdipine 3 μg/kg can effectively prevent pituitrin‐induced cardiovascular responses in the patients undergoing laparoscopic myomectomy .