中药联合全身化疗和(或)动脉灌注化疗治疗胰腺癌肝转移的回顾性研究

A Retrospective Study of Chinese Herbal Medicine Combined with Systemic Chemotherapy and/or Regional Arterial Perfusion for Pancreatic Cancer with Liver Metastases

目的评价中药联合全身化疗和(或)动脉灌注化疗治疗胰腺癌肝转移(pancreatic cancer with liver metastases,PCLM)的疗效及安全性。方法回顾性分析天津医科大学肿瘤医院2001—2010年10年间采用中药联合全身化疗和(或)区域性动脉灌注治疗的292例PCLM患者,其中西医治疗组157例,中西医治疗组135例。对西医治疗组患者采用含吉西他滨(GEM)的方案化疗,其中部分患者接受区域性动脉灌注治疗;中西医治疗组在接受上述治疗的同时持续口服清热消积中药4周以上。观察中位生存时间(median survival time,MST)、不良反应及并发症发生率。结果两组患者的一般资料比较,差异无统计学意义(P>0.05)。西医治疗组和中西医治疗组的MST分别为4.8、5.5个月,差异有统计学意义(P<0.05)。全组无化疗或动脉灌注治疗相关性死亡,毒副反应均可耐受。结论中药联合全身化疗和(或)动脉灌注治疗安全有效,可作为PCLM姑息治疗的优先选择。

Objective To evaluate the efficacy and safety of Chinese herbal medicine combined with systemic chemotherapy and/or regional arterial perfusion for pancreatic cancer with liver metastases（PCLM）.Methods We retrospectively selected 292 patients with PCLM who were treated by Chinese herbal medicine combined with systemic chemotherapy and/or regional arterial perfusion at Tianjin Medical University Cancer Hospital from January 2001 to December 2010.All patients were assigned to the Western medicine treatment group（157 cases） and the integrative medicine treatment group（135 cases）.Patients in the Western medicine treatment group were treated with gemcitabine（GEM）-based chemotherapy,and partial of them received regional arterial perfusion.Those in the integrative medicine treatment group additionally took Chinese herbs of clearing heat and eliminating mass for at least 4weeks.The median survival time（MST）,adverse reactions and the incidence of complications were observed.Results There was no statistical significance in general data between the two groups（P 〉0.05）.There was statistical difference in MST between the two groups（4.8 months vs 5.5 months,P〈0.05）.No death occurred during chemotherapy or regional arterial perfusion.All toxic or adverse reactions were tolerable.Conclusion Chinese herbal medicine combined with systemic chemotherapy and/or regional arterial perfusion was effective and safe,and it could be optimally selected as palliative therapy for PCLM.