复方清热颗粒对病毒感染急性期患者淋巴细胞亚群表达的影响

Effect of Compound Qingre Granule on the Expression of Peripheral Blood Lymphocyte Subsets of Acute Virus Infection Patients

目的观察中药复方清热颗粒对病毒感染急性期患者细胞免疫功能的干预作用。方法将30例病毒感染急性期患者分为两组,分别给予抗病毒治疗(简称西药组)或抗病毒联合中药复方清热颗粒治疗(简称中西医组)。观察治疗前、治疗7天后外周血淋巴细胞亚群变化,并与健康对照者(20名,作为正常对照组)比较。结果与正常对照比较,病毒感染急性期患者外周血T细胞比例升高,B细胞及NK细胞比例降低(P<0.01);T细胞亚群中,CD4^+T细胞、CD4^+CD28^+T细胞、CD8^+CD28^+T细胞比例降低,CD8^+T细胞、CD8^+CD38^+T细胞比例升高(P<0.05,P<0.01)。治疗7天后,患者CD4^+T细胞、CD4^+CD28^+T细胞及CD8^+CD28^+T细胞比例较治疗前增高(P<0.05,P<0.01),CD8^+CD38^+T细胞比例降低(P<0.01),且CD4^+T、CD4^+/CD8^+、CD8^+CD28^+T及CD8^+CD38^+T中西医组改变程度优于西药组(P<0.05)。结论病毒感染急性期患者存在细胞免疫功能紊乱,中药复方清热颗粒联合抗病毒治疗可明显改善病毒感染导致的免疫紊乱及免疫损伤。

Objective To observe interventional effects of anti-viral therapy and Compound Qingre Granule（CQG） on host cellular immune functions of acute virus infection patients.Methods Thirty acute virus infection patients were recruited to detect peripheral lymphocyte subsets.They were randomly assigned to two groups,the Western medicine treatment group（treated with anti-virus Western medicine） and the integrative medicine treatment group（treated with anti-virus Western medicine plus CQG）.T-cell subsets were re-examined 7 days later.Changes between before and after treatment were observed.Effect on host cellular immune functions and efficacy were compared between the Western medicine treatment and the integrative medicine treatment.Results Compared with the normal control group,the percentage of peripheral T cells increased,and the percentage of B/NK cells decreased in acute virus infection patients（P 〈0.01）.Meanwhile,in T cell subsets,the percentage of CD8~＋T cells and CD8~＋ CD38~＋ T cells increased（P 〈0.05,P 〈0.01）;and percentages of CD4~＋ T cells,CD4~＋ CD28~＋ T cells,and CD8~＋ CD28~＋T cells decreased（P〈0.05,P〈0.01）.After one-week treatment,percentages of CD4~＋T cells,CD4~＋ CD28~＋ T cells,and CD8~＋ CD28~＋ T cells increased（P 〈0.05,P 〈0.01）,while the percentage of CD8~＋ CD38~＋T cells decreased（P 〈0.01）.More significantly,these changes were greater in the integrative medicine treatment group than in the Western medicine treatment group（P 〈0.05）.Conclusions Disarranged cellular immune functions existed in acute virus infection patients.CQG could significantly improve viral infection induced immunologic derangement and immunologic injury.