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GnRH 脉冲治疗非肥胖多囊卵巢综合征患者的不孕症 被引量:13

Management of infertility in patients with non-obese polycystic ovary syndrome by micro-pulse infusion of GnRH
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摘要 采用皮下脉冲输注促性腺激素释放激素(GnRH)治疗非肥胖 PCOS 不孕症患者。其中,1例32岁患者经治疗后,月经规律来潮,自然受孕并产下健康男婴。提示 GnRH 脉冲治疗可诱导非肥胖 PCOS不孕症患者自发排卵、自然受孕。 [Summary] Patients with infertility and non-obese polycystic ovary syndrome ( PCOS) were treated with continuous subcutaneous pulse infusion of GnRH. After the treatment, a 32-year old female had regular menstrual cramps. Dominant follicle occurred after 2 months of treatment. The patient was pregnant and now has a healthy baby boy. It shows that the pulse infusion of GnRH could induce spontaneous ovulation and natural fertilization of the patients with non-obese PCOS.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2015年第6期528-529,共2页 Chinese Journal of Endocrinology and Metabolism
基金 上海市卫生和计划生育委员会科研课题(201440528)
关键词 垂体激素泵 GNRH 脉冲治疗 非肥胖 PCOS 妊娠 Pituitary hormone pump Micro-pulse infusion of GnRH Non-obese polycystic ovarian syndrome(PCOS) Pregnancy
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参考文献3

  • 1Raivio T, Falardeau J, Dwyer A, et al. Reversal of idiopathic hypogonadotropic hypogonadism[J]. N Engl J Med, 2007,357(9):863-873.
  • 2Mattle V, Bilgyicildirim A, Hadziomerovic D, et al. Polycystic ovarian disease unmasked by pulsatile GnRH therapy in a subgroup of women with hypothalamic amenorrhea[J]. Fertil Steril, 2008,89(2):404-409.
  • 3孙首悦,王卫庆,蒋怡然,王毅峰,叶俊娜,张曼娜,周伟,詹维伟,李小英,宁光.微量泵脉冲输注戈那瑞林治疗特发性低促性腺激素性性腺功能减退症[J].中华内分泌代谢杂志,2011,27(8):654-658. 被引量:41

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