应力下IGF-Ⅰ对颞下颌关节软骨的作用的研究进展

Research progress of the role of IGF-Ⅰ in temporomandibular joint cartilage under stress

颞下颌关节应力敏感区中的髁突软骨与下颌骨发育和改建有着密切关系,髁突软骨在应力作用下能够响应力学刺激,从而促进髁突软骨细胞的增殖以及分化。胰岛素样生长因子(insulin-like growth factor,IGF)-Ⅰ在髁突软骨生长发育中有着重要影响,通过与受体的结合,发挥生物学效应,而且IGF-Ⅰ在应力刺激下会促使髁突软骨合成,参与髁突的改建。本文主要阐述IGF-Ⅰ及其在应力作用下在颞下颌关节的相关表现,旨在进一步明确应力下IGF-Ⅰ在颞下颌关节软骨中的作用机制。

The condylar cartilage in TMJ （temporomandibular joint） stress sensitive area is closely related to the growth and remode- ling of the mandible. Under stress, condylar cartilage can respond to mechanical stimuli, thereby contributing to the proliferation and dif- ferentiation of condylar cartilage cells. IGF （ insulin-like growth factor） -Ⅰ plays an important part in the growth and development of the condylar cartilage,and has a biological effect by binding itself to receptors. Meanwhile,IGF-Ⅰ under stress stimuli will lead to the syn- thesis of condylar cartilages and is involved in condylar remodeling. This article focused on IGF-Ⅰ and its relevant performance in the temporomandibular joint under stress, so as to further clarify the mechanism of IGF-Ⅰ in temporomandibular joint cartilage under stress.