摘要
冠脉支架术后再狭窄是严重且高发的医学事件。局部血流动力学因素,特别是壁面剪切应力(WSS),对冠脉粥样硬化斑块的形成、发展和不均匀性有着重要的影响。最近的基础和临床在体研究表明,WSS也可能与支架内再狭窄的发生有关。从支架内再狭窄的形成机制出发,分析冠脉支架后的力学环境对再狭窄的作用机制,详细阐述近年基于计算流体力学(CFD)方法的冠脉支架内再狭窄的血流动力学研究进展。
Coronary stent restenosis is a high incidence and severe medical event. Local hemodynamic factors, wall shear stress （WSS） in particular, critically affect the formation, progression and heterogeneity of atherosclerotic plaque. Emerging preclinical and clinical in vivo evidences now suggest that WSS may also contribute to the occurrence of stent restenosis. This review starts from the formation mechanism of in-stent restenosis, analyzes the mechanism of mechanical environment in coronary stent restenosis and elaborates the computational fluid dynamics （CFD） research progress in haemodynamics associated with in-stent restenosis in detail.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2015年第3期354-359,共6页
Chinese Journal of Biomedical Engineering
基金
北京市自然科学基金(3112011)
