急性胰腺炎临床特征的单中心研究(附4800例报告)

Clinical features of acute pancreatitis from a single-center study:4800 cases report

目的：研究急性胰腺炎（AP）病人的临床流行病学特征。方法：收集1996-2012年本院收治的4 800例AP病人,分析性别、年龄、病因学及预后等临床特征及变化趋势。结果 ：男2 832例（59.0%）,女1 968例（41.0%）,平均年龄分别为（51.5±16.6）岁、（54.1±17.4）岁,发病年龄随时间无明显变化。胆源性（69.0%）、高脂血症性（7.4%）及酒精性（2.3%）是前三位原因。胆源性AP比例稳定（1996-2000年61.9%,2001-2006年70.7%,2007-2012年70.8%）;高脂血症性AP比例明显上升AP（1996-2000年2.6%,2001-2006年6.6%,2007-2012年14.1%）;酒精性AP比例轻度上升（1996-2000年1.4%,2001-2006年1.7%,2007-2012年3.3%）。各病因之间死亡率无统计学差异（P=0.18）。总体死亡率为4.7%,呈现下降趋势（1996-2000年5.3%,2001-2006年4.8%,2007-2012年4.2%）。平均住院时间为（25.0±34.5）d,住院费用为（75 750±18 000）元（2012可比价格计算）,两者均呈下降趋势。结论 ：51-60岁为AP最多发年龄段,胆源性是最主要病因,高脂血症性AP增加最显著。

Objective To explore the clinical features and changes in the prevalence of acute pancreatitis（AP）.Methods A retrospective study was conducted with 4 800 admissions diagnosed AP in our hospital from 1996 to 2012.The changes in gender, age, etiology, and prognosis were analyzed. Results There were 2 832（59.0%） men and 1 968（41.0%） women with mean age of male（51.5 ±16.6） years and female（54.1±17.4） years without variations in age in this period. Gallstones（69.0%）, hyperlipidemia（7.4%） and alcoholism（2.3%） were the top three common causes. The ratio of biliary AP was stable（61.9% from 1996 to 2000, 70.7% from 2001 to 2006 and 70.8% from 2007 to 2012） and that of hyperlipidemic AP increased obviously（2.6%, 6.6% and 14.1% respectively） and alcoholic AP increased slightly（1.4%,1.7% and 3.3% respectively）. Etiology-related mortality presented no difference（P =0.18）. The mortality was 4.7% and decreased during the period of study from 5.3%（1996-2000） to 4.8%（2001-2006） to 4.2%（2007-2012）. The average hospital stay was（25.0±34.5） days and expense（75 750±18 000） RMB, and both decreased in the period of this study.Conclusions The population aging 51-60 was the most vulnerable group for AP all along. Biliary AP was the predominant type of AP and the proportion of hyperlipidemic AP increased obviously.