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尼曼匹克C1样蛋白1及其与胆囊胆固醇结石形成关系的研究进展 被引量：1

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摘要 脂质代谢异常与胆固醇结石病、动脉粥样硬化、冠心病等疾病发生关系密切。尼曼匹克C1样蛋白1（Niemann Pick C1 like 1,NPC1L1）是小肠参与胆固醇摄取的重要蛋白质[1],自其被发现以来,一直是研究和临床关注的热点。本文对NPC1L1蛋白及其基因多态性研究的最新成果作一综述,并对其在相关疾病治疗中的作用作一展望。
作者 吴健 蒋兆彦
机构地区 上海交通大学医学院附属瑞金医院外科上海消化外科研究所
出处 《外科理论与实践》 2015年第3期262-265,共4页 Journal of Surgery Concepts & Practice
关键词 尼曼匹克C1样蛋白1 胆固醇 基因多态性 胆固醇结石病 冠心病
分类号 R575.62 [医药卫生—消化系统]
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参考文献33

  • 1Altmann SW, Davis HR Jr, Zhu LJ, et al. Niemann-PickCl Like 1 protein is critical for intestinal cholesterol ab-sorption[J]. Science,2004,303(5661): 1201-1204.
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二级参考文献15

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外科理论与实践
2015年 第3期

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