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Cellular reprogramming and inherited peripheral neuropathies: perspectives and challenges

Cellular reprogramming and inherited peripheral neuropathies: perspectives and challenges
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摘要 Inherited peripheral neuropathies （or Charcot-Marie-Tooth disease, CMT） are a phenotypically and genetically heterogeneous group of disorders, which are currently untreatable. They are the most common inherited neuromuscular disorder, affecting around 1 in every 2,500 people （over 120,000 people in the US）. Based on clinical neurophysiological and histopathological features, inherited neuropathies can be divided into two major forms： demyelinating （type 1） and axonal （type 2） CMT （Saporta, 2014）. Inherited peripheral neuropathies （or Charcot-Marie-Tooth disease, CMT） are a phenotypically and genetically heterogeneous group of disorders, which are currently untreatable. They are the most common inherited neuromuscular disorder, affecting around 1 in every 2,500 people （over 120,000 people in the US）. Based on clinical neurophysiological and histopathological features, inherited neuropathies can be divided into two major forms： demyelinating （type 1） and axonal （type 2） CMT （Saporta, 2014）.
作者 Mario A.Saporta
机构地区 Department of Neurology
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第6期894-896,共3页 中国神经再生研究（英文版）
关键词 gene CMT Cellular reprogramming and inherited peripheral neuropathies perspectives and challenges LITAF
分类号 R745 [医药卫生—神经病学与精神病学]
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Neural Regeneration Research
2015年 第6期

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