补肾活血方治疗激素性兔股骨头无菌坏死

Experimental Study of Treatment of Steroid-induced Avascular Necrosis of Femoral Head with Bushen Huoxue Recipe

目的:探讨补肾活血方治疗激素性股骨头缺血性坏死的机理。方法:将24只激素性兔股骨头缺血坏死模型随机分为对照组、模型组、中药组,于灌胃治疗8周后处死,分别进行血脂、X线、股骨头骨密度及组织学的观察及测定。结果:中药组总胆固醇为(2.23±0.34)mmol/L、甘油三脂为(1.53±0.21)mmol/L、股骨头空骨陷窝率为(23.35±1.43)%,均明显低于模型组的(3.15±0.41)mmol/L,(2.31±0.32)mmol/L,(34.67±2.15)%。中药组股骨头骨密度为(0.539±0.038)g/cm2,新生血管数为(7.4±2.1)条,均高于模型组的(0.515±0.026)g/cm2、(5.2±1.4)条,结论:补肾活血方可以降低血脂,增加骨密度,促进坏死骨吸收和新骨形成。

ObjectiveTo explore the mechanism of steroid-induced avascular necrosis of femoral headtreated by Bushen Huoxue Recipe.MethodsTwenty-four rabbits were randomly divided into three groups：the control group, the sham control group and the Traditional Chinese Medicine group. Acetic acid hydropredni-sone 8 mg/Kg via gastrogavage was given after establishment of the animal model for 8 weeks. All rabbits werekilled and serum lipid, X-ray film, the number of empty lacuna and bone mineral density of femoral head wereobserved and measured.ResultsIn the Traditional Chinese Medicine group, levels of total cholesterol was（2.23±0.34）mmol/L, triglyceride was（1.53±0.21）mmol/L, the rate of empty lacuna was（23.35±1.43）%. Allthese values were lower than those in the sham control group. Bone mineral density of femoral head[（0.539 ±0.038）g/cm2] and the amount of new blood vessels（7.4 ± 2.1）in the Traditional Chinese Medicine group werehigher than those in the sham control group.ConclusionBushen Huoxue Recipe can reduce serum lipid, in-crease bone mineral density and absorption of necrosis of bone, and promote formation of new bone. The experi-ment provides a theoretical basis for treatment of necrosis of the femoral head.