可疑青光眼患者视野指数与眼底血管变化的关系

Relationship between visual field measurements and retinal oxygen saturation in suspected glaucoma patients

目的探讨可疑青光眼者眼底血氧饱和度的基本特征及其与视野指数的关系。方法采用横断面研究设计,对可疑青光眼者及正常对照者应用视网膜血氧饱和度测量仪测量眼底血氧饱和度,同时进行中心30°阈值视野检测;统计分析平均视网膜光敏感度(MS)、平均视野缺损度(MD)及丢失方差(LV)三个视野指数,以及视网膜血氧饱和度,并进行相关分析。结果可疑青光眼者与正常者MD存在统计学差异(P<0.05);可疑青光眼者平均视网膜动脉血氧饱和度及视网膜鼻下支动脉血氧饱和度与正常者比较存在统计学差异(P<0.05);可疑青光眼者视野检测的MD与NIA存在相关性,(r=0.368,P=0.045)。结论可疑青光眼者眼底血管可能发生了相应的变化,视网膜血氧饱和度状况与视野指数间存在一定联系。

Objective To evaluate the relationship between visual field measurements and retinal oxygen satura-tion （Sat O 2 ）in suspected glaucoma patients. Methods A cross sectional study design was performed. The glaucoma suspects were examined with spectrophotometric retinal oximeter （Oxymap ehf,Reykjavik,Iceland）for Sat O 2 ,and with Octopus-101 perimetry with G2 strategy for visual field. SPSS 20. 0 was used for data analysis of retinal oxygen saturation, mean sensitivity （MS）,mean defect （MD）,and loss variance （LV）. The relationship between these visual field indices and retinal oxygen saturation were examined using Pearson product moment correlation coefficient. Results The mean de-fect （MD）,mean retinal Sat O2 in retinal arterioles （MA）and retinal arterioles of inferonasal quadrant （NIA）were sig-nificantly different in glaucoma suspects compared to normal eyes （P 〈 0. 05）. In patients with suspected glaucoma,there was a correlation between MD and NIA （r = 0. 368,P = 0. 045）. Conclusion Changed retinal vasculature functions may be found in patients with suspected glaucoma and it could be correlated with the changes in visual field.