摘要
目的研究载脂蛋白E(apolipoprotein E,Apo E)基因多态性与非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)发病的关系。方法全面检索和筛选相关文献,并进行Meta分析,计算OR值及95%CI,并评价其发表偏倚,运用敏感性分析评价结果的可靠性。结果实际纳入文献5篇,包括932例NAFLD患者,1 703例对照者。以野生型ε3/3基因型及等位基因ε3为参照,Meta分析研究发现,总体分析中Apo Eε2、ε4等位基因及基因型ε2/2、ε2/3、ε2/4、ε3/4、ε4/4在NAFLD患者中的分布频率与对照组比较,差异无统计学意义(P〉0.05)。亚组分析发现中国人群Apo E基因多态性与NAFLD发病风险无相关性,在欧洲人群的研究中,ε2/3 vsε3/3(P=0.002,OR=0.50,95%CI:0.32~0.77)、ε2等位基因携带者(ε2/2+ε2/3)vsε3/3(P=0.04,OR=0.59,95%CI:0.35~0.98),差异有统计学意义;ε2/3基因型与欧洲人群NAFLD的发生具有相关性。结论 NAFLD的发生与中国人群Apo E基因多态性无明显相关性,但ε2/3基因型可能是欧洲人群NAFLD的保护因素。
Objective To evaluate the correlation between apolipoprotein E (ApoE) gene polymorphism and nonal- coholic fatty liver disease (NAFLD). Methods The published studies on the association between ApoE gene polymor- phism and NAFLD were included. A Meta-analysis was employed to summarize all these studies, P values, the pooled OR and its 95% CI were calculated, and the overall effects were tested. The Egger' s publication bias analysis and sensi- tivity analysis were carried out to evaluate the reliability and stability of the Meta-analysis. Results A total of 5 litera- tures were retrieved. Nine hundred and thirty-two patients with NAFLD and 1 703 controls were included. Wild-type genotype ε3/3 and allele e3 were regarded as a reference, Meta-analysis revealed that no remarkable heterogeneities were discovered in the allele ε2, ε4 and genotype ε2/2, ε2/3, ε2/4, e3/4, ε4/4 of ApoE between NAFLD and con- trol groups in the overall analysis. Subgroup analysis found that there was no correlation between ApoE gene polymor- phism and the risk of NAFLD in Chinese. In European populations, there were significant differences in ε2/3 vs ε3/3 (P=0.002, 0R=0.50, 95%CI: 0.32-0.77) and allele carrier ε2 (ε2/2+ε2/3) vs ε3/3 (P =0. 04,OR =0. 59, 95% CI:0. 35 -0. 98) ; ε2/3 genotype was statistically correlated with NAFLD. Conclusion ApoE gene polymorphism has no significant correlation with the occurrence of NAFLD in Chinese, but in Europeans, e2/3 genotype might be cor- related with NAFLD.
出处
《胃肠病学和肝病学杂志》
CAS
2015年第6期674-678,共5页
Chinese Journal of Gastroenterology and Hepatology